Zheng Li-Fang, Chen Pei-Jie, Xiao Wei-Hua
School of Kinesiology, Shanghai University of Sports, Shanghai 200438, China.
Sheng Li Xue Bao. 2019 Jun 25;71(3):497-504.
Insulin resistance is a common pathophysiological mechanism of obesity and type 2 diabetes mellitus. Skeletal muscle is one of the major target organs of insulin-mediated glucose uptake, metabolism and utilization, and it is the earliest and most important site of insulin resistance. Studies have shown that the impairments of glucose uptake, insulin signaling pathway and mitochondrial biosynthesis are closely related to skeletal muscle insulin resistance. When insulin resistance develops in skeletal muscle, multiple microRNAs (miRNAs) are up-regulated (miR-106b, miR-23a, miR-761, miR-135a, Let-7 and miR-29a) or down-regulated (miR-133a, miR-149 and miR-1). They participate in the regulation of skeletal muscle glucose uptake, insulin signaling pathway and mitochondrial biogenesis, and thus play important roles in the occurrence and development of skeletal muscle insulin resistance. Therefore, these miRNAs may serve as potential targets for the treatment of skeletal muscle insulin resistance or diabetes.
胰岛素抵抗是肥胖症和2型糖尿病常见的病理生理机制。骨骼肌是胰岛素介导的葡萄糖摄取、代谢及利用的主要靶器官之一，也是胰岛素抵抗最早且最重要的部位。研究表明，葡萄糖摄取、胰岛素信号通路及线粒体生物合成的受损与骨骼肌胰岛素抵抗密切相关。当骨骼肌发生胰岛素抵抗时，多种微小RNA（miRNA）会上调（miR-106b、miR-23a、miR-761、miR-135a、Let-7及miR-29a）或下调（miR-133a、miR-149及miR-1）。它们参与骨骼肌葡萄糖摄取、胰岛素信号通路及线粒体生物合成的调控，进而在骨骼肌胰岛素抵抗的发生发展中发挥重要作用。因此，这些miRNA可能成为治疗骨骼肌胰岛素抵抗或糖尿病的潜在靶点。
