Iwasa Takeshi, Matsuzaki Toshiya, Mayila Yiliyasi, Kawakita Takako, Yanagihara Rie, Irahara Minoru
Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Gynecol Endocrinol. 2020 Jan;36(1):55-60. doi: 10.1080/09513590.2019.1631276. Epub 2019 Jun 21.
Polycystic ovary syndrome (PCOS) is commonly associated with metabolic disorders, which are exacerbated by obesity. Recent studies have revealed that oxytocin contributes to metabolic, appetite, and body weight regulation. In the present study, we evaluated the effects of chronic administration of oxytocin on body weight, food intake, and fat mass in a dihydrotestosterone-induced rat model of PCOS. Body weight, body weight change, and relative cumulative food intake were significantly lower in the oxytocin-treated PCOS rats than in the vehicle-treated control PCOS rats. Similarly, visceral adipocyte size was significantly smaller in the oxytocin-treated PCOS rats than in the vehicle-treated control PCOS rats. On the other hand, the numbers of cystic follicles in the ovary did not differ between the two groups. The chronic administration of oxytocin did not affect the rats' serum aspartate aminotransferase, alanine aminotransferase, or lactate dehydrogenase levels, indicating that it does not have adverse effects on hepatic function. These findings suggest that oxytocin could be a candidate drug for preventing the onset of obesity-related metabolic disorders in PCOS patients.
多囊卵巢综合征（PCOS）通常与代谢紊乱有关，肥胖会加剧这种紊乱。最近的研究表明，催产素有助于调节代谢、食欲和体重。在本研究中，我们评估了在二氢睾酮诱导的PCOS大鼠模型中，长期给予催产素对体重、食物摄入量和脂肪量的影响。与接受赋形剂处理的对照PCOS大鼠相比，接受催产素处理的PCOS大鼠的体重、体重变化和相对累积食物摄入量显著更低。同样，与接受赋形剂处理的对照PCOS大鼠相比，接受催产素处理的PCOS大鼠的内脏脂肪细胞大小显著更小。另一方面，两组之间卵巢中的囊性卵泡数量没有差异。长期给予催产素对大鼠血清天冬氨酸转氨酶、丙氨酸转氨酶或乳酸脱氢酶水平没有影响，表明它对肝功能没有不良影响。这些发现表明，催产素可能是预防PCOS患者肥胖相关代谢紊乱发生的候选药物。
