Department of General Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang 325003, China; Institute of Basic Medical, The Second Military Medical University, Shanghai 200433, China.
Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
Pancreatology. 2019 Jul;19(5):751-759. doi: 10.1016/j.pan.2019.01.009. Epub 2019 Jan 31.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplastic disease, characterized with poor outcomes and a 5-year survival rate less than 5%. Dysregulation or dysfunction of immune response factors contribute to cancer development. In this study, we found that OCIAD1 is high expressed in pancreatic cancer gene chip, and verified OCIAD1 associating with cancer malignancy in specimens from patients with PDAC. OCIAD1 down-regulation inhibited PDAC cell lines migration and vice versa. Further analysis of pancreatic cancer gene chip found OCIAD1 high expression was associating with low ATM expression. Then we proved that OCIAD1 regulated ATM to affect the migration of PDAC. Thus we concluded that high OCIAD1 levels in PDAC promoted tumor cells migration. OCIAD1 exerted its effects by regulating ATM.
胰腺导管腺癌 (PDAC) 是一种侵袭性肿瘤疾病，其特点是预后不良，5 年生存率低于 5%。免疫反应因子的失调或功能障碍导致癌症的发生。在这项研究中，我们发现 OCIAD1 在胰腺癌基因芯片中高表达，并在 PDAC 患者的标本中验证了 OCIAD1 与癌症恶性程度相关。OCIAD1 的下调抑制了 PDAC 细胞系的迁移，反之亦然。对胰腺癌基因芯片的进一步分析发现，OCIAD1 高表达与 ATM 表达降低相关。然后我们证明 OCIAD1 通过调节 ATM 来调节 PDAC 的迁移。因此，我们得出结论，OCIAD1 在 PDAC 中的高水平促进了肿瘤细胞的迁移。OCIAD1 通过调节 ATM 发挥作用。
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