长期太空任务的抗衰老效果，通过心率变异性评估。
Anti-aging effects of long-term space missions, estimated by heart rate variability.
机构信息
Executive Medical Center, Totsuka Royal Clinic, Tokyo Women's Medical University, Tokyo, Japan.
Halberg Chronobiology Center, University of Minnesota, Minneapolis, Minnesota, USA.
出版信息
Sci Rep. 2019 Jun 20;9(1):8995. doi: 10.1038/s41598-019-45387-6.
Reports that aging slows down in space prompted this investigation of anti-aging effects in humans by analyzing astronauts' heart rate variability (HRV). Ambulatory 48-hour electrocardiograms from 7 astronauts (42.1 ± 6.8 years; 6 men) 20.6 ± 2.7 days (ISS01) and 138.6 ± 21.8 days (ISS02) after launch were divided into 24-hour spans of relative lower or higher magnetic disturbance, based on geomagnetic measures in Tromso, Norway. Magnetic disturbances were significantly higher on disturbed than on quiet days (ISS01: 72.01 ± 33.82 versus 33.96 ± 17.90 nT, P = 0.0307; ISS02: 71.06 ± 51.52 versus 32.53 ± 27.27 nT, P = 0.0308). SDNNIDX was increased on disturbed days (by 5.5% during ISS01, P = 0.0110), as were other HRV indices during ISS02 (SDANN, 12.5%, P = 0.0243; Triangular Index, 8.4%, P = 0.0469; and TF-component, 17.2%, P = 0.0054), suggesting the action of an anti-aging or longevity effect. The effect on TF was stronger during light (12:00-17:00) than during darkness (0:00-05:00) (P = 0.0268). The brain default mode network (DMN) was activated, gauged by increases in the LF-band (9.7%, P = 0.0730) and MF1-band (9.9%, P = 0.0281). Magnetic changes in the magnetosphere can affect and enhance HRV indices in space, involving an anti-aging or longevity effect, probably in association with the brain DMN, in a light-dependent manner and/or with help from the circadian clock.
报告称，太空中的衰老速度会减缓，这促使人们通过分析宇航员的心率变异性（HRV）来研究人类的抗衰老效果。对 7 名宇航员（42.1±6.8 岁；6 名男性）的 48 小时动态心电图进行了分析，这些宇航员在发射后 20.6±2.7 天（ISS01）和 138.6±21.8 天（ISS02）时的心电图被分为相对较低或较高磁场干扰的 24 小时跨度，磁场干扰是根据挪威特罗姆瑟的地磁测量结果划分的。ISS01 期间，干扰日的磁场干扰明显高于安静日（72.01±33.82 对 33.96±17.90 nT，P=0.0307）；ISS02 期间，干扰日的磁场干扰也明显高于安静日（71.06±51.52 对 32.53±27.27 nT，P=0.0308）。ISS01 期间，SDNNIDX 升高（增加了 5.5%，P=0.0110），ISS02 期间其他 HRV 指数也升高（SDANN，增加 12.5%，P=0.0243；三角指数增加 8.4%，P=0.0469；TF 成分增加 17.2%，P=0.0054），这表明存在抗衰老或长寿效应。TF 的影响在光照期间（12:00-17:00）比在黑暗期间（0:00-05:00）更强（P=0.0268）。大脑默认模式网络（DMN）被激活，低频带（LF）增加了 9.7%（P=0.0730），中频带 1（MF1）增加了 9.9%（P=0.0281）。磁层中的磁场变化会影响和增强太空中的 HRV 指数，这涉及到抗衰老或长寿效应，可能与大脑 DMN 有关，这种影响依赖于光照，或者需要生物钟的帮助。
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