延胡索酸酶介导对营养应激的转录反应。

Fumarase mediates transcriptional response to nutrient stress.

作者信息

Zhao Qin, Jiang Yuhui

机构信息

The Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200080, China.

出版信息

Cell Stress. 2017 Oct 1;1(1):68-69. doi: 10.15698/cst2017.10.107.

DOI:10.15698/cst2017.10.107

PMID:31225435

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6551652/

Abstract

Limited supply of nutrient normally causes cell growth arrest. Our recent study (Nat Cell Biol. (7):833-843) shows that fumarase (FH), a key enzyme responsible for the conversion between fumarate and malate in tricarboxylic acid cycle, is importantly involved in the cellular response to nutrient condition.

摘要

营养物质供应受限通常会导致细胞生长停滞。我们最近的研究（《自然细胞生物学》。(7):833 - 843）表明，延胡索酸酶（FH），一种负责三羧酸循环中延胡索酸和苹果酸之间转化的关键酶，在细胞对营养状况的反应中起着重要作用。