非多肽可透析胸腺因子对IgE抗体产生的抑制作用。
Suppression of IgE-antibody production by non-polypeptide dialysable thymic factor.
作者信息
Bezvershenko I, Gjulling E, Dyugovskaya L
出版信息
Immunology. 1979 Feb;36(2):229-34.
The effect of dialysable thymic extract on the IgE-antibody production in rats was studied. A marked suppression of IgE-antibody production determined by mast cell degranulation and passive cutaneous anaphylaxis tests was found in the immunized rats injected with dialysable thymic extract. The treatment of this preparation with immobilized pronase affects neither its suppressive activity, nor does such treatment affect the activity of purified factor, isolated from the crude extract. The prolonged administration of purified preparation to rats leads to an increase in thymus weight. When syngeneic thymocytes incubated with purified non-polypeptide thymic factor were administered to immunized rats a significant suppression of IgE-antibody production was observed compared to that occurring in untreated ones. On this basis, it was concluded that a decrease of IgE-antibody production may be due to a direct stimulation of T-suppressor cells.
研究了可透析胸腺提取物对大鼠IgE抗体产生的影响。在注射了可透析胸腺提取物的免疫大鼠中，通过肥大细胞脱颗粒和被动皮肤过敏试验确定，IgE抗体产生受到显著抑制。用固定化链霉蛋白酶处理该制剂既不影响其抑制活性，也不影响从粗提取物中分离出的纯化因子的活性。向大鼠长期施用纯化制剂会导致胸腺重量增加。当将与纯化的非多肽胸腺因子一起孵育的同基因胸腺细胞施用于免疫大鼠时，与未处理的大鼠相比，观察到IgE抗体产生受到显著抑制。在此基础上，得出结论，IgE抗体产生的减少可能是由于T抑制细胞的直接刺激。
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