Morozov V G, Khavinson V Kh, Kozhemiakin A L, Kozhemiakin L A
Vopr Med Khim. 1982 Jul-Aug;28(4):114-8.
Thyramine, a polypeptide factor from thymus, at wide range of concentrations increased the cAMP content in rat thymocytes. Increase in the cAMP content was less distinct in spleen lymphoid cells. Thyramine decreased the cGMP content in thymocytes; minimal nucleotide level was found within 15 min of incubation. The data obtained suggest that the rate of lymphocyte maturation is important for response of the cells to the effect of immunoregulating agents.
胸腺素是一种来自胸腺的多肽因子，在很宽的浓度范围内可增加大鼠胸腺细胞中的环磷酸腺苷（cAMP）含量。在脾淋巴细胞中，cAMP含量的增加不太明显。胸腺素可降低胸腺细胞中的环磷酸鸟苷（cGMP）含量；在孵育15分钟内可发现核苷酸水平降至最低。所获得的数据表明，淋巴细胞成熟速率对于细胞对免疫调节因子作用的反应很重要。
