大鼠的行为遗传学研究。

Behavioral Genetic Studies in Rats.

作者信息

Ren Yangsu, Palmer Abraham A

机构信息

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.

出版信息

Methods Mol Biol. 2019;2018:319-326. doi: 10.1007/978-1-4939-9581-3_16.

DOI:10.1007/978-1-4939-9581-3_16

PMID:31228165

Abstract

In this chapter, we briefly review the use of rats as a genetic model for the study of behavior. Rats were the first mammalian species used for genetic and biological research. Since the development of the first inbred rat strain in 1909, more than 700 unique inbred and outbred rat lines have been generated. Although rats have been somewhat eclipsed by mice in the last few decades, a renewed appreciation of the advantages of rats for behavioral and other types of research is upon us. We briefly review the pertinent characteristics of the rat and highlight the key advantages of using the rat to examine behavioral phenotypes.

摘要

在本章中，我们简要回顾将大鼠用作行为研究的遗传模型的情况。大鼠是首个用于遗传和生物学研究的哺乳动物物种。自1909年首个近交系大鼠品系培育成功以来，已培育出700多个独特的近交和远交大鼠品系。尽管在过去几十年里大鼠在一定程度上被小鼠超越，但现在我们对大鼠在行为及其他类型研究中的优势有了新的认识。我们简要回顾大鼠的相关特征，并着重介绍使用大鼠来研究行为表型的关键优势。