Bazin B, Thevenot R, Bursaux C, Paris J
Clinical Department, Les Mercuriales Tour-Est, Bagnolet, France.
Br J Obstet Gynaecol. 1987 Dec;94(12):1199-204. doi: 10.1111/j.1471-0528.1987.tb02322.x.
After two control cycles, 13 normally menstruating women were treated from day 5 to 25 of the third consecutive cycle with nomegestrol acetate (NOM Ac) 1.25, 2.5 or 5 mg once a day. Plasma oestradiol, FSH and LH concentrations were assayed daily from day 5 to day 25 and plasma progesterone concentrations from day 12 to day 25. Ovulation was inhibited in every woman; LH and progesterone levels were uniformly depressed. With 5 and 2.5 mg/day, plasma oestradiol remained low with high FSH values. With 1.25 mg/day, oestradiol concentrations reached levels similar to those achieved during the control follicular phase, with a concomitant decrease in FSH secretion. These results show an hypothalamic-pituitary effect and suggest an ovarian action, both responsible for a potentially useful contraceptive property.
经过两个对照周期后，13名月经正常的女性在第三个连续周期的第5天至第25天接受醋酸诺美孕酮（NOM Ac）治疗，剂量分别为1.25毫克、2.5毫克或5毫克，每日一次。从第5天至第25天每天测定血浆雌二醇、促卵泡生成素（FSH）和促黄体生成素（LH）浓度，从第12天至第25天测定血浆孕酮浓度。所有女性的排卵均受到抑制；LH和孕酮水平均一致降低。每天服用5毫克和2.5毫克时，血浆雌二醇水平较低，FSH值较高。每天服用1.25毫克时，雌二醇浓度达到与对照卵泡期相似的水平，同时FSH分泌减少。这些结果显示了下丘脑-垂体效应，并提示存在卵巢作用，二者共同导致了一种潜在有用的避孕特性。
