Institute of Applied Synthetic Chemistry, Vienna University of Technology, Austria.
Doping Control Laboratory, Seibersdorf Labor GmbH, Austria.
Steroids. 2019 Oct;150:108430. doi: 10.1016/j.steroids.2019.108430. Epub 2019 Jun 20.
A long-term metabolite of the doping agent oxymetholone (OXM-M2, 17β-hydroxymethyl-2,17α-methyl-18-norandrost-13-en-3-one) which has been identified by GC-MS/MS was synthesized from commercially available materials. Two efficient synthetic routes to access both C-17 epimers of tentative metabolites were developed. The identity and molecular configuration of the in vivo metabolite: 17β-hydroxymethyl-2α,17α-methyl-18-norandrost-13-en-3-one was confirmed by single crystal X-ray diffraction.
GC-MS/MS 鉴定出兴奋剂羟甲烯龙（OXM-M2，17β-羟甲基-2,17α-甲基-18-去甲雄甾-13-烯-3-酮）的一种长期代谢物，并由市售材料合成得到。开发了两种高效的合成路线，以获得两种暂定代谢物的 C-17 差向异构体。通过单晶 X 射线衍射证实了体内代谢物 17β-羟甲基-2α,17α-甲基-18-去甲雄甾-13-烯-3-酮的结构和分子构型。
