转录调控与生物能量学交叉点上的细胞色素氧化酶
Cytochrome Oxidase on the Crossroads of Transcriptional Regulation and Bioenergetics.
作者信息
Chicherin Ivan Vladimirovich, Dashinimaev Erdem, Baleva Mariia, Krasheninnikov Igor, Levitskii Sergey, Kamenski Piotr
机构信息
Department of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Institute of Functional Genomics, Lomonosov Moscow State University, Moscow, Russia.
出版信息
Front Physiol. 2019 May 24;10:644. doi: 10.3389/fphys.2019.00644. eCollection 2019.
Abstract
Mitochondria are the organelles of eukaryotic cells responsible for the ATP production by means of the electron transfer chain (ETC). Its work is under strict genetic control providing the correct assembly of the enzyme complexes and the interface to adapt the energetic demands of the cell to the environment. These mechanisms are particularly developed in the cells with high energy consumption, like neurons and myocytes. This review summarizes several aspects of the involvement of the ETC complexes in the transcriptional control mechanisms of the neurons and other cells. Their influence on the differentiation of neurons is also discussed.
摘要
线粒体是真核细胞中的细胞器，负责通过电子传递链（ETC）产生三磷酸腺苷（ATP）。其工作受到严格的基因控制，以确保酶复合物的正确组装以及使细胞的能量需求与环境相适应的界面。这些机制在高能量消耗的细胞中尤为发达，如神经元和肌细胞。本综述总结了ETC复合物参与神经元和其他细胞转录控制机制的几个方面。还讨论了它们对神经元分化的影响。
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