Liu Fanming, Wang Qi, Qian Yuzhen, Zhang Yejun, Zhang Bingqiang, Li Hongyan, Zou Wei
College of Life Sciences, Liaoning Normal University, Dalian 116081, Liaoning, China.
Liaoning Key Laboratory of Biotechnology and Molecular Drug Development, Dalian 116081, Liaoning, China.
Sheng Wu Gong Cheng Xue Bao. 2019 Jun 25;35(6):1021-1028. doi: 10.13345/j.cjb.180529.
Adenosine 5'-monophosphate-activated protein activated protein kinase (AMPK), a heterotrimeric complex, is an important kinase to regulate glycolipid metabolism and energy balance involved in a variety physiological processes in human body. Many research indicated that the function and activity of AMPK were closely related to inflammation, diabetes and cancers. Recent reports show that inhibition of metformin (a first-line drug) on hepatic glucose in patients with hyperglycemia is associated with AMPK pathway, suggesting that targeting AMPK may be one of the effective strategies for the prevention and treatment of a variety of chronic diseases. Here, we review research progress on the structure, activation and regulation of AMPK in glycolipid metabolism to provide an insight into the basic and clinical research of diabetes therapy.
5'-单磷酸腺苷激活蛋白激酶（AMPK）是一种异源三聚体复合物，是调节糖脂代谢和能量平衡的重要激酶，参与人体多种生理过程。许多研究表明，AMPK的功能和活性与炎症、糖尿病和癌症密切相关。最近的报告显示，二甲双胍（一种一线药物）对高血糖患者肝脏葡萄糖的抑制作用与AMPK途径有关，这表明靶向AMPK可能是预防和治疗多种慢性疾病的有效策略之一。在此，我们综述了AMPK在糖脂代谢中的结构、激活和调节方面的研究进展，以期为糖尿病治疗的基础和临床研究提供参考。
