脉冲式皮下注射促性腺激素释放激素与外源性促性腺激素治疗孤立性低促性腺激素性性腺功能减退男性的比较。
Comparison of pulsatile subcutaneous gonadotropin-releasing hormone and exogenous gonadotropins in the treatment of men with isolated hypogonadotropic hypogonadism.
作者信息
Liu L, Chaudhari N, Corle D, Sherins R J
机构信息
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
出版信息
Fertil Steril. 1988 Feb;49(2):302-8. doi: 10.1016/s0015-0282(16)59720-9.
Eight men with isolated hypogonadotropic hypogonadism were treated with pulsatile gonadotropin-releasing hormone (GnRH) after maximal testicular growth and function had already been achieved with human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG). Only four subjects could normalize plasma testosterone (T) levels (group A). After 18 months of GnRH therapy, testicular size of group A increased by 53% (P less than 0.01) over that previously attained with exogenous gonadotropins. However, despite further testicular growth, two men who were previously azoospermic on hCG/hMG remained so on GnRH. In the other two patients, total sperm count increased minimally. Thus, pulsatile gonadotropin levels achieved with GnRH are more effective in stimulating testicular growth, but not necessarily sperm output, than are stable gonadotropin concentrations obtained with hCG/hMG.
八名患有孤立性促性腺激素缺乏性性腺功能减退的男性，在使用人绒毛膜促性腺激素（hCG）和人绝经期促性腺激素（hMG）已使睾丸达到最大生长和功能后，接受了脉冲式促性腺激素释放激素（GnRH）治疗。只有四名受试者能够使血浆睾酮（T）水平恢复正常（A组）。GnRH治疗18个月后，A组睾丸大小比之前使用外源性促性腺激素时增加了53%（P<0.01）。然而，尽管睾丸进一步生长，但之前在hCG/hMG治疗下无精子症的两名男性在GnRH治疗后仍无精子。在另外两名患者中，总精子计数仅有少量增加。因此，与hCG/hMG所获得的稳定促性腺激素浓度相比，GnRH所产生的脉冲式促性腺激素水平在刺激睾丸生长方面更有效，但不一定能增加精子产量。
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