Wollina Uwe
Dresden Municipal Hospital, Dresden Academic Teaching Hospital, Dresden, Germany.
Acta Dermatovenerol Alp Pannonica Adriat. 2019 Jun;28(2):53-55.
Chronic exposure to sunlight accelerates extrinsic aging due to changes in the extracellular matrix. Cutis rhomboidalis nuchae and erythrosis interfollicularis colli are two benign skin disorders related to extrinsic aging.
The study investigated possible co-occurrence in 50 male patients that developed skin cancer due to professional outdoor work, and demonstrated cutis rhomboidalis nuchae clinically and by dermoscopy.
The study observed 11 cases of co-existent erythrosis interfollicularis colli characterized by perifollicular white halos in dermoscopy. These patients had Fitzpatrick skin type II or III but not type I. The severity of erythrosis interfollicularis colli was diminished in the area of cutis rhomboidalis nuchae. Basal cell carcinomas were seen in only one patient on the borders of cutis rhomboidalis nuchae, whereas erythrosis interfollicularis colli did not prevent development of basal cell carcinomas. Actinic keratoses were seen in nine of 11 patients with erythrosis interfollicularis colli, but not with cutis rhomboidalis skin.
This study argues for a local protective effect of cutis rhomboidalis nuchae against other ultraviolet light-induced cutaneous pathologies.
长期暴露于阳光下会因细胞外基质的变化而加速外源性老化。项部菱形皮肤和颈部毛囊间红斑是两种与外源性老化相关的良性皮肤疾病。
该研究调查了50名因职业户外工作而患皮肤癌的男性患者中这两种疾病可能的共存情况，并通过临床检查和皮肤镜检查证实了项部菱形皮肤的存在。
该研究观察到11例共存的颈部毛囊间红斑患者，其皮肤镜检查表现为毛囊周围白色晕圈。这些患者的皮肤类型为Fitzpatrick II型或III型，但没有I型。颈部毛囊间红斑的严重程度在项部菱形皮肤区域有所减轻。仅1例患者在项部菱形皮肤边缘出现基底细胞癌，而颈部毛囊间红斑并未阻止基底细胞癌的发生。11例颈部毛囊间红斑患者中有9例出现光化性角化病，但项部菱形皮肤患者未出现。
本研究表明项部菱形皮肤对其他紫外线诱导的皮肤病变具有局部保护作用。
