University of Chinese Academy of Sciences, Shanghai, China.
Chinese Academy of Sciences, Shanghai, China.
Arthritis Care Res (Hoboken). 2020 Sep;72(9):1305-1314. doi: 10.1002/acr.24013.
Little is known about how metabolic perturbations are linked to hyperuricemia in the general population. Therefore we aimed to examine metabolomics profiles in relation to uric acid change and incident hyperuricemia.
This study included 1,621 community-dwelling Chinese participants ages 50-70 years without hyperuricemia at baseline, with a mean duration of follow-up of 6 years. A total of 56 metabolites (22 amino acids and 34 acylcarnitines) at baseline were quantified by gas or liquid chromatography coupled to mass spectrometry. Annual change in uric acid was calculated, and incident hyperuricemia was defined as plasma uric acid >420 μmoles/liter in men and >360 μmoles/liter in women.
The mean ± SD annual change in uric acid was 9.6 ± 12.1 μmoles/liter and the incidence of hyperuricemia was 23.1% (375 of 1,621). After adjustment for conventional risk factors, 9 metabolites (cysteine, glutamine, phenylalanine, threonine, and long-chain acylcarnitines C14:1OH, C18, C18:2, C20, and C20:4) were significantly associated with uric acid change (Bonferroni corrected P < 0.05) and with incident hyperuricemia (relative risks ranged from 1.14 to 1.21 per SD increment of metabolites; P < 0.05). A network analysis showed significant associations between the module containing long-chain acylcarnitines and incident hyperuricemia. Moreover, levels of these 9 metabolites were specifically correlated with intake of foods, including red and processed meat or soy products.
Plasma cysteine, glutamine, phenylalanine, threonine, and long-chain acylcarnitines are positively associated with incident hyperuricemia. The levels of these metabolites may be partially driven by intakes of meat and soy products that are associated with hyperuricemia.
人群中，代谢紊乱与高尿酸血症的关系知之甚少。因此，我们旨在研究尿酸变化与高尿酸血症发病相关的代谢组学特征。
本研究纳入了 1621 名年龄在 50-70 岁、基线时无高尿酸血症的社区居民，中位随访时间为 6 年。通过气相或液相色谱-质谱联用技术检测基线时的 56 种代谢物（22 种氨基酸和 34 种酰基辅酶 A）。计算尿酸的年变化量，高尿酸血症定义为男性血尿酸＞420μmol/L，女性＞360μmol/L。
尿酸的平均年变化量为 9.6±12.1μmol/L，高尿酸血症的发病率为 23.1%（1621 名患者中有 375 名）。在调整了传统危险因素后，9 种代谢物（半胱氨酸、谷氨酰胺、苯丙氨酸、苏氨酸和长链酰基辅酶 A C14：1OH、C18、C18：2、C20 和 C20：4）与尿酸变化显著相关（Bonferroni 校正后 P＜0.05），与高尿酸血症发病相关（代谢物每增加 1 个标准差，相对风险范围为 1.14-1.21；P＜0.05）。网络分析显示，包含长链酰基辅酶 A 的模块与高尿酸血症发病显著相关。此外，这 9 种代谢物的水平与包括红肉和加工肉类或豆制品在内的食物摄入呈特异性相关。
血浆半胱氨酸、谷氨酰胺、苯丙氨酸、苏氨酸和长链酰基辅酶 A 与高尿酸血症发病呈正相关。这些代谢物的水平可能部分受与高尿酸血症相关的肉类和豆制品摄入的影响。
