Amin Reham F, El Bendary Amal S, Ezzat Sherif E, Mohamed Waleed S
Internal Medicine Department, Tanta Faculty of Medicine, Al-Sinbellawein General Hospital, Egypt.
Clinical Pathology Department, Faculty of Medicine, Tanta University, Egypt.
Diabetes Metab Syndr. 2019 May-Jun;13(3):2226-2229. doi: 10.1016/j.dsx.2019.05.030. Epub 2019 May 25.
Non-alcoholic fatty liver disease (NAFLD) was considered one of the most common causes of chronic liver disease and is considered the hepatic manifestation of type 2 diabetes mellitus (T2DM). The factors that lead to marked fibrosis and liver cell injury in NAFLD are still remaining undiscovered.
This study included (40) type 2 diabetic patients with NAFLD and (40) diabetic patients without NAFLD beside 15 healthy persons as a control group. All of them were subjected to full history taking, thorough clinical examination with especial stress on body weight (BW), height, body mass index (BMI), waist-hip ratio, blood pressure. Laboratory tests included serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high-density lipoprotein (HDL), fasting blood glucose (FBG) and 2-h postprandial blood glucose (PBG), serum Ferritin and urine microalbuminuria (MAU).
Duration of diabetes, BW, BMI and blood pressure were significantly higher in NAFLD group (P = 0.001). FBG, PBG, TC, TG, LDL, serum Ferritin and MAU were significantly increased in NAFLD group with significant difference between two studied groups as regard HDL. There was a highly significant correlation between serum Ferritin with BW, BMI, duration of diabetes, TC, TG, LDL and MAU. There was a significant correlation between serum Ferritin with age, waist hip ratio, duration of diabetes, SBP, FBG, PBG and HDL. There was a significant correlation between MAU and age, weight, BMI, waist hip ratio, duration of diabetes, DBP, FBG TC, TG, LDL and HDL.
NAFLD is a common liver disorder in diabetic patients. NAFLD is significantly associated with microalbuminuria and elevated serum Ferritin.
非酒精性脂肪性肝病（NAFLD）被认为是慢性肝病最常见的病因之一，被视为2型糖尿病（T2DM）的肝脏表现。导致NAFLD中显著纤维化和肝细胞损伤的因素仍未被发现。
本研究纳入了40例患有NAFLD的2型糖尿病患者、40例无NAFLD的糖尿病患者以及15名健康人作为对照组。对所有受试者进行了全面的病史采集、详细的临床检查，尤其着重于体重（BW）、身高、体重指数（BMI）、腰臀比、血压。实验室检查包括血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）、空腹血糖（FBG）和餐后2小时血糖（PBG）、血清铁蛋白和尿微量白蛋白（MAU）。
NAFLD组的糖尿病病程、BW、BMI和血压显著更高（P = 0.001）。NAFLD组的FBG、PBG、TC、TG、LDL、血清铁蛋白和MAU显著升高，两组在HDL方面存在显著差异。血清铁蛋白与BW、BMI、糖尿病病程、TC、TG、LDL和MAU之间存在高度显著相关性。血清铁蛋白与年龄、腰臀比、糖尿病病程、收缩压、FBG、PBG和HDL之间存在显著相关性。MAU与年龄、体重、BMI、腰臀比、糖尿病病程、舒张压、FBG、TC、TG、LDL和HDL之间存在显著相关性。
NAFLD是糖尿病患者中常见的肝脏疾病。NAFLD与微量白蛋白尿和血清铁蛋白升高显著相关。
