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免疫介导性结核性葡萄膜炎——一种罕见的与坏死性结节性结核疹相关的疾病。

Immune-mediated tuberculous uveitis - A rare association with papulonecrotic tuberculid.

机构信息

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

出版信息

Indian J Ophthalmol. 2019 Jul;67(7):1207-1209. doi: 10.4103/ijo.IJO_1550_18.

Abstract

The tuberculids are a group of distinct clinicopathological form of skin lesions representing hypersensitivity reaction to hematogenous dissemination of Mycobacterium tuberculosis or its antigen from an underlying active or a silent focus of tuberculosis elsewhere in the body in an individual with a strong antituberculous cell-mediated immunity and by definition do not show bacilli on special stains and are culture-negative. Ocular involvement can occur in tuberculosis, both due to direct invasion by the bacilli as well as an immune-mediated reaction; however, immune-mediated tuberculous uveitis occurring as a hypersensitivity response in association with PNT has hardly been reported in the literature. Here we report one such rare case.

摘要

结核菌素疹是一组独特的临床病理皮肤损害,代表了对结核分枝杆菌血行播散或其抗原的超敏反应,这种超敏反应发生于机体对结核分枝杆菌具有强大的细胞介导免疫应答的个体中,其潜在的活动性或隐匿性结核病灶在其他部位,这些病灶通过特殊染色和培养均未发现杆菌。眼部受累可发生于结核病,这既可以是由杆菌直接侵犯引起,也可以是免疫介导反应所致;然而,文献中很少有报道称,与 PNT 相关的作为超敏反应发生的免疫介导性结核性葡萄膜炎。在此,我们报告了这样一个罕见病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/6611300/156a7107e08f/IJO-67-1207-g001.jpg

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