Llorens-Cortes C, Gros C, Schwartz J C
Unité 109 de Neurobiologie et Pharmacologie, Centre Paul Broca de l'INSERM, Paris, France.
NIDA Res Monogr. 1986;75:275-8.
The tripeptide Tyr-Gly-Gly (YGG), an extraneuronal metabolite of opioid peptides (OP) derived from proenkephalin A is in a highly dynamic state in mouse striatum. Inhibition of its synthesis by Thiorphan reduced its levels with a t 1/2 of 12 min. Inhibition of its degradation by bestatin elicited its rapid accumulation consistent with a t 1/2 of enkephalins in the one-hour range. Pentobarbital anesthesia markedly reduced its steady state level and turnover rates.
三肽酪氨酸-甘氨酸-甘氨酸（YGG）是源自前脑啡肽A的阿片肽（OP）的一种神经外代谢产物，在小鼠纹状体中处于高度动态状态。硫羟吗啡抑制其合成会使YGG水平降低，半衰期为12分钟。贝司他汀抑制其降解会使其迅速积累，这与脑啡肽在一小时范围内的半衰期一致。戊巴比妥麻醉显著降低了其稳态水平和周转率。
