Broderick P A
Department of Neurology, Cornell Univ. Med. Coll., Burke Rehab. Ctr., White Plains, New York 10605.
NIDA Res Monogr. 1986;75:367-70.
Centrally problematic in the study of drugs of abuse is the addictive process itself. Addictive drugs affect dopaminergic nigrostriatal and mesolimbic neuronal circuitry during brain reward. These findings show that cocaine produces a decrease in dopamine release from rat striatum and prevents the surge of dopamine release which occurs post-mortem. The results suggest that dopaminergic control over striatal neuronal membrane may be important in neurochemical mechanisms underlying brain reward.
在滥用药物研究中，核心问题在于成瘾过程本身。成瘾性药物在大脑奖赏过程中会影响多巴胺能黑质纹状体和中脑边缘神经元回路。这些研究结果表明，可卡因会使大鼠纹状体中的多巴胺释放减少，并阻止死后出现的多巴胺释放激增。结果表明，多巴胺能对纹状体神经元膜的控制在大脑奖赏的神经化学机制中可能很重要。
