Frenking G, Loew G H, Lawson J
Life Sciences Division, SRI International, Menlo Park, California 94025.
NIDA Res Monogr. 1986;75:53-6.
The theoretically determined molecular structures of N-protonated 1,3,4,6 methyl-substituted 4-(m-OH phenyl) piperidines are correlated to their experimentally derived analgesic activities. It is concluded that the orientation of the 3-methyl group plays a crucial role in determining agonism and antagonism.
N-质子化的1,3,4,6-甲基取代的4-(间羟基苯基)哌啶的理论确定分子结构与其实验得出的镇痛活性相关。得出的结论是，3-甲基的取向在决定激动作用和拮抗作用方面起着关键作用。
