Baskin D S, Hosobuchi Y
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030.
NIDA Res Monogr. 1986;75:531-4.
Cats were treated using a blinded protocol with either the dextrorotary or levorotary form of WIN 44,441-3 injected subcutaneously six hours after middle cerebral artery occlusion, followed by continuous subcutaneous infusion. The levorotary form acutely improved neurologic function in 90% of animals, whereas the dextrorotary form had no effect. Survival rate and infarct size were the same in both groups. These results further implicate the kappa receptor in the pathophysiology of cerebral ischemia.
采用盲法方案对猫进行治疗，在大脑中动脉闭塞6小时后，皮下注射右旋或左旋形式的WIN 44,441-3，随后进行持续皮下输注。左旋形式能使90%的动物神经功能急性改善，而右旋形式则无效。两组的存活率和梗死面积相同。这些结果进一步表明κ受体参与了脑缺血的病理生理过程。
