急性脊髓损伤后是否需要进行骨质疏松症的预防？
Is prophylaxis for osteoporosis indicated after acute spinal cord injury?
作者信息
Dionyssiotis Yannis
机构信息
Physical Medicine and Rehabilitation Clinic, General University Hospital of Ioannina, Ioannina, Greece.
出版信息
Spinal Cord Ser Cases. 2019 Feb 27;5:24. doi: 10.1038/s41394-019-0167-y. eCollection 2019.
Abstract
Spinal cord injury (SCI)-related osteoporosis is common complication in people with tetraplegia or paraplegia. Studies have shown that sublesional regions are severely demineralized. Loss of bone and sequential fractures are major problems in people with SCI that lead to further immobilization and decreasing quality of life. Despite extensive research mechanisms of this bone impairment are inadequately understood. This article discusses basics of bone metabolism physiopathology along with pharmaceutical prevention and treatment approaches to manage acute SCI-related bone loss.
摘要
脊髓损伤（SCI）相关的骨质疏松症是四肢瘫痪或截瘫患者常见的并发症。研究表明，损伤节段以下区域严重脱矿质。骨质流失和相继发生的骨折是脊髓损伤患者的主要问题，会导致进一步的活动受限和生活质量下降。尽管进行了广泛研究，但这种骨质损害的机制仍未得到充分了解。本文讨论了骨代谢生理病理学的基础知识以及治疗急性SCI相关骨质流失的药物预防和治疗方法。
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Osteoporos Int. 2016 Jan;27(1):405-10. doi: 10.1007/s00198-015-3333-5. Epub 2015 Sep 30.
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