Department of Urology, Lanzhou University Second Hospital, Lanzhou, China.
Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas.
J Cell Physiol. 2020 Feb;235(2):1013-1024. doi: 10.1002/jcp.29017. Epub 2019 Jun 25.
Iron is an essential metal ion in the human body and usually dysregulated in cancers. However, a comprehensive overview of the iron-related genes and their clinical relevance in cancer is lacking. In this study, we utilized the expression profiling, proteomics, and epigenetics from the Cancer Genome Atlas database to systematically characterized the alterations of iron-related genes. There were multiple iron-related genes with dysregulation across 14 cancers and some of these ectopic changes may be associated with aberrant DNA methylation. Meanwhile, a variety of genes were significantly associated with patient survival, especially in kidney renal clear cell carcinoma. Then differentially expressed genes were validated in clinical samples. Finally, we found deferoxamine and erastin could inhibit proliferation in various tumor cells and influence the expression of several iron-related genes. Overall, our study provides a comprehensive analysis of iron metabolism across cancers and highlights the potential treatment of iron targeted therapies for cancers.
铁是人体内必需的金属离子，通常在癌症中失调。然而，目前缺乏对与铁相关的基因及其在癌症中的临床相关性的全面概述。在这项研究中，我们利用癌症基因组图谱数据库中的表达谱、蛋白质组学和表观遗传学，系统地描述了与铁相关基因的改变。在 14 种癌症中，有多个铁相关基因失调，其中一些异位变化可能与异常的 DNA 甲基化有关。同时，许多基因与患者的生存显著相关，特别是在肾透明细胞癌中。然后在临床样本中验证差异表达基因。最后，我们发现去铁胺和 erastin 可以抑制多种肿瘤细胞的增殖，并影响几种铁相关基因的表达。总的来说，我们的研究提供了对癌症中铁代谢的全面分析，并强调了针对铁的靶向治疗癌症的潜在治疗方法。
