Department of the 4th Internal Medicine, Xi'an Chest Hospital, Xi'an, Shaanxi, China.
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Mol Genet Genomic Med. 2019 Aug;7(8):e770. doi: 10.1002/mgg3.770. Epub 2019 Jun 26.
Tuberculosis (TB) is a significant worldwide health problem, and is caused by Mycobacteria tuberculosis. Recent studies have suggested that FOXO3 plays vital roles in the risk of immune-related infectious diseases such as TB.
The present study aimed to evaluate FOXO3 genetic variants and TB risk. We recruited 510 TB patients and 508 healthy controls in this study. All subjects were genotyped with the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression adjusted for age and gender. Our result revealed that rs3800229 T/G and rs4946935 G/A genotypes significantly increased the risk of TB (OR = 1.34, 95% CI = 1.04-1.74, p = 0.026; OR = 1.34, 95% CI = 1.03-1.73, p = 0.029, respectively). In stratified analysis according to gender and age, we observed that rs3800229 T/G and rs4946935 G/A genotypes were associated with an increase the risk of TB among males and age ≤41 years, respectively (OR = 1.47, 95% CI = 1.06-2.04, p = 0.022 and OR = 1.45, 95% CI = 1.05-2.02, p = 0.025).
Our study showed that rs3800229 and rs4946935 in FOXO3 were associated with a risk of TB in the Chinese population.
结核病（TB）是一个严重的全球健康问题，由结核分枝杆菌引起。最近的研究表明，FOXO3 在免疫相关传染病（如 TB）的风险中发挥着重要作用。
本研究旨在评估 FOXO3 遗传变异与 TB 风险的关系。我们招募了 510 例 TB 患者和 508 例健康对照进行这项研究。所有受试者均使用 Agena MassARRAY 平台进行基因分型。使用 logistic 回归模型调整年龄和性别后，计算比值比（OR）和 95%置信区间（CI）。我们的结果表明，rs3800229 T/G 和 rs4946935 G/A 基因型显著增加了 TB 的发病风险（OR=1.34，95%CI=1.04-1.74，p=0.026；OR=1.34，95%CI=1.03-1.73，p=0.029）。根据性别和年龄进行分层分析，我们观察到 rs3800229 T/G 和 rs4946935 G/A 基因型与男性和≤41 岁人群中 TB 风险增加相关（OR=1.47，95%CI=1.06-2.04，p=0.022 和 OR=1.45，95%CI=1.05-2.02，p=0.025）。
我们的研究表明，FOXO3 中的 rs3800229 和 rs4946935 与中国人群的 TB 发病风险相关。
