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右心室导线诱发的室性心律失常——心脏再同步治疗的一种罕见并发症。

Right ventricular lead induced ventricular arrhythmia-A rare complication of cardiac resynchronization therapy.

作者信息

Miśkowiec Dawid, Życiński Paweł, Qawoq Dariusz H, Pagórek Piotr, Zając Piotr, Chudzik Michał, Wcisło Tomasz, Kasprzak Jarosław D

机构信息

Department of Cardiology, Medical University of Lodz, Lodz, Poland.

出版信息

Ann Noninvasive Electrocardiol. 2019 Sep;24(5):e12666. doi: 10.1111/anec.12666. Epub 2019 Jun 26.

DOI:10.1111/anec.12666
PMID:31241241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6931888/
Abstract

BACKGROUND

A 53-year-old male with heart failure secondary to anterior wall myocardial infarction treated with cardiac resynchronization-defibrillator (CRT-D) device presented with ventricular arrhythmia: repetitive incessant slow ventricular tachycardias (VT) below the CRT-D detection zone, accelerated ventricular rhythm, and numerous premature ventricular ectopic beats (ExV), resulting in loss of biventricular pacing.

METHODS AND RESULTS

Nonsustained monomorphic VT (nsVT) and ExV were observed in an electrocardiogram under biventricular stimulation. During noninvasive CRT-D programming, ventricular bigeminy reproducibly recurred only at right ventricular (RV) pacing and its morphology was almost identical to the stimulated beats. The left ventricular (LV) pacing failed to induce ventricular ectopy or tachycardia.

CONCLUSIONS

This unusual case shows a rare phenomenon of late proarrhythmic effect due to the RV lead pacing-a new finding reported only in a few publications. Here we present our approach to CRT programming that suppressed the clinical arrhythmia without the need of catheter ablation and achieving the high biventricular pacing capture rate along with optimal hemodynamic CRT-D performance.

摘要

背景

一名53岁男性,因前壁心肌梗死继发心力衰竭,接受心脏再同步除颤器(CRT-D)治疗,出现室性心律失常:CRT-D检测区以下反复不停的缓慢室性心动过速(VT)、加速性室性心律以及大量室性早搏(ExV),导致双心室起搏丧失。

方法与结果

在双心室刺激下的心电图中观察到非持续性单形性室速(nsVT)和ExV。在无创CRT-D程控期间,室性二联律仅在右心室(RV)起搏时反复出现,其形态与刺激后的搏动几乎相同。左心室(LV)起搏未能诱发室性异位搏动或心动过速。

结论

该罕见病例显示了右心室导线起搏引起的迟发性促心律失常效应这一罕见现象——仅有少数出版物报道过这一新发现。在此,我们展示了我们的CRT程控方法,该方法无需导管消融即可抑制临床心律失常,并实现高双心室起搏捕获率以及最佳的血流动力学CRT-D性能。

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本文引用的文献

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Right ventricular lead proarrhythmia: A novel intervention for an under-recognized phenomenon.右心室导联致心律失常:对一种未被充分认识现象的新干预措施。
HeartRhythm Case Rep. 2017 Dec 12;4(2):50-53. doi: 10.1016/j.hrcr.2017.10.009. eCollection 2018 Feb.
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Left ventricular-only pacing in heart failure patients with normal atrioventricular conduction improves global function and left ventricular regional mechanics compared with biventricular pacing: an adaptive cardiac resynchronization therapy sub-study.左心室-only 起搏在房室传导正常的心力衰竭患者中改善整体功能和左心室节段力学,优于双心室起搏:适应性心脏再同步治疗亚研究。
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The differences in the relationship between diastolic dysfunction, selected biomarkers and collagen turn-over in heart failure patients with preserved and reduced ejection fraction.射血分数保留和降低的心力衰竭患者舒张功能障碍、选定生物标志物与胶原周转之间关系的差异。
Cardiol J. 2017;24(1):35-42. doi: 10.5603/CJ.a2016.0098. Epub 2016 Oct 17.
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2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.2016欧洲心脏病学会急性和慢性心力衰竭诊断与治疗指南:欧洲心脏病学会(ESC)急性和慢性心力衰竭诊断与治疗工作组编写,欧洲心脏病学会心力衰竭协会(HFA)提供特别贡献。
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A case of premature ventricular contractions, ventricular tachycardia, and arrhythmic storm induced by right ventricular pacing during cardiac resynchronization therapy: Electrophysiological mechanism and catheter ablation.心脏再同步治疗期间右心室起搏诱发室性早搏、室性心动过速和心律失常风暴1例:电生理机制及导管消融
J Arrhythm. 2015 Dec;31(6):401-5. doi: 10.1016/j.joa.2015.06.002. Epub 2015 Jul 15.
6
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7
An individual patient meta-analysis of five randomized trials assessing the effects of cardiac resynchronization therapy on morbidity and mortality in patients with symptomatic heart failure.一项针对五个随机试验的个体患者荟萃分析,评估心脏再同步治疗对有症状心力衰竭患者的发病率和死亡率的影响。
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Meta-analysis of randomized controlled trials evaluating left ventricular vs. biventricular pacing in heart failure: effect on all-cause mortality and hospitalizations.随机对照试验的荟萃分析评估心力衰竭患者左心室与双心室起搏的效果:全因死亡率和住院率的影响。
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Effects of cardiac resynchronization therapy on long-term quality of life: an analysis from the CArdiac Resynchronisation-Heart Failure (CARE-HF) study.心脏再同步治疗对长期生活质量的影响:来自心脏再同步化治疗心力衰竭(CARE-HF)研究的分析。
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