Women's College Research Institute, Toronto, ON, Canada.
Department of Obstetrics and Gynecology, Women's College Hospital, Toronto, ON, Canada.
Climacteric. 2020 Feb;23(1):32-37. doi: 10.1080/13697137.2019.1627315. Epub 2019 Jun 26.
Women with Turner syndrome (TS) are at increased risk for chronic health conditions. Reports describing the presence of comorbidities in older adult women with TS are limited. This study aimed to examine the prevalence of endocrine, gynecological, and other chronic medical conditions in a cohort of adult TS patients. A retrospective chart review was conducted on patients seen between 1 February 2015 and 1 July 2018 in a multidisciplinary TS clinic at a university-based ambulatory hospital in Toronto, Canada. All women seen at the TS clinic with a diagnosis of TS aged >18 years were included. The prevalence of diseases was determined overall and stratified by age (<40 and ≥40 years). Statistical comparisons were done using the chi-square test. The main study outcomes included the presence of comorbidities. Of 122 adult women with TS, 24.5% had hypothyroidism, 16% had dysglycemia, and 27.9% had decreased bone mass. Hypothyroidism and dysglycemia were more common among older women (respectively age ≥40 years vs. age <40 years: 36.7% vs. 17.8%, = 0.018; and 24.5% vs. 5.5%, = 0.023). Gynecological conditions were identified in 35% of patients and were more common among older women (42.8% age ≥40 years vs. 13.7% age <40 years, = 0.003). Overall, 41% had hearing impairment, 36.1% had cardiac abnormalities, 14.8% had hypertension, 18.8% had renal abnormalities, and 9% had celiac disease. The results of this study indicate a high prevalence of medical conditions in women with TS, especially those ≥40 years of age. Our study underscores the importance of multidisciplinary adult TS clinics for ongoing screening and management of comorbidities.
特纳综合征（TS）女性患慢性健康问题的风险增加。描述老年 TS 女性患者合并症存在情况的报告有限。本研究旨在检查多学科 TS 诊所的一组成年 TS 患者中内分泌、妇科和其他慢性疾病的患病率。对 2015 年 2 月 1 日至 2018 年 7 月 1 日期间在加拿大安大略省多伦多市一所大学门诊医院的多学科 TS 诊所就诊的所有年龄>18 岁、诊断为 TS 的女性患者进行了回顾性图表审查。总体和按年龄（<40 岁和≥40 岁）分层确定疾病的患病率。使用卡方检验进行统计比较。主要研究结果包括合并症的存在。在 122 名成年 TS 女性中，24.5%患有甲状腺功能减退症，16%患有血糖异常，27.9%存在骨量减少。甲状腺功能减退症和血糖异常在老年女性中更为常见（年龄≥40 岁与年龄<40 岁分别为 36.7%和 17.8%， = 0.018；24.5%和 5.5%， = 0.023）。在 35%的患者中发现了妇科疾病，且在老年女性中更为常见（年龄≥40 岁与年龄<40 岁分别为 42.8%和 13.7%， = 0.003）。总体而言，41%的患者有听力障碍，36.1%的患者有心脏异常，14.8%的患者有高血压，18.8%的患者有肾脏异常，9%的患者有乳糜泻。本研究结果表明，TS 女性患多种疾病的患病率很高，尤其是年龄≥40 岁的女性。我们的研究强调了多学科成人 TS 诊所对合并症进行持续筛查和管理的重要性。
