阳离子抗菌肽治疗结核病：小型综述。
Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review.
机构信息
Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Júlio Amaral de Carvalho, 45, 4200-135 Porto, Portugal.
出版信息
Curr Protein Pept Sci. 2019;20(9):885-892. doi: 10.2174/1389203720666190626160057.
Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms. This review discusses the principal properties of natural and/or synthetic CAMPs, and how these new peptides have a significant specificity for Mycobacterium tuberculosis. Also, we propose some alternative strategies to enhance the therapeutic activity of these CAMPs that include coadministration with nanoparticles and/or classic drugs.
阳离子抗菌肽（CAMPs）可以被认为是一种具有特定氨基酸序列的新型潜在抗结核治疗药物。未来可以开展新的研究来改善 CAMPs 的药理学特性，并了解可能的耐药机制。本文讨论了天然和/或合成 CAMPs 的主要特性，以及这些新肽如何对结核分枝杆菌具有显著的特异性。此外，我们还提出了一些增强这些 CAMPs 治疗活性的替代策略，包括与纳米颗粒和/或经典药物联合给药。
Zotero 插件