J Assoc Nurses AIDS Care. 2019 Jul-Aug;30(4):392-404. doi: 10.1097/JNC.0000000000000022.
People living with HIV (PLWH) experience high rates of fatigue, which can be improved with physical activity. We examined relationships between HIV infection, fatigue, cardiorespiratory fitness, physical activity, and myokines. Twenty PLWH and 20 HIV-uninfected adults completed a fatigue assessment, a maximal cardiometabolic exercise test, serum measures of myokines, and wore an accelerometer for 7 days. Measures were completed at baseline, 3 months, and 6 months. At baseline, PLWH had more fatigue (4.7 ± 2.6 vs. 2.8 ± 2.5, p = .01) and higher peak ventilatory efficiency (VE/VCO2; 33 ± 5.5 vs. 30.2 ± 2.5; p = .06). Half of PLWH engaged in at least one 10-minute bout of physical activity in the previous week, compared with control subjects (65%). Over time, HIV infection and fibroblast growth factor 21 were associated with fatigue (p < .05). People living with HIV have more fatigue and a higher ventilatory efficiency; expression of fibroblast growth factor 21 may underpin this relationship.
HIV 感染者（PLWH）经历高疲劳率，可以通过身体活动得到改善。我们研究了 HIV 感染、疲劳、心肺功能适应性、身体活动和肌肉因子之间的关系。20 名 HIV 感染者和 20 名 HIV 未感染者完成了疲劳评估、最大心肺运动试验、肌肉因子的血清测量以及佩戴了 7 天的加速度计。在基线、3 个月和 6 个月时完成了测量。在基线时，PLWH 的疲劳程度更高（4.7 ± 2.6 对 2.8 ± 2.5，p =.01），峰值通气效率（VE/VCO2）更高（33 ± 5.5 对 30.2 ± 2.5；p =.06）。与对照组相比，一半的 PLWH 在过去一周内至少进行了一次 10 分钟的身体活动（65%）。随着时间的推移，HIV 感染和成纤维细胞生长因子 21 与疲劳相关（p <.05）。HIV 感染者的疲劳程度更高，通气效率更高；成纤维细胞生长因子 21 的表达可能是这种关系的基础。
