对液体复苏无反应的重症登革热休克患者给予大剂量甲基强的松龙和甘露醇后的血流动力学反应。

Hemodynamic response to high-dose methyl prednisolone and mannitol in severe dengue-shock patients unresponsive to fluid replacement.

作者信息

Futrakul P, Poshyachinda M, Mitrakul C, Kwakpetoon S, Unchumchoke P, Teranaparin C, Kheokham K, Impand C

机构信息

Department of Pediatrics, Faculty of Medicine, Chulalongkorn Medical School Hospital, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 1987 Sep;18(3):373-9.

PMID:3124276

Abstract

Nine children; 4 males and 5 females, aged ranging from 2 1/2 to 13 years presented with signs and symptoms of poor tissue perfusion associated with dengue shock syndrome. All these 9 patients were subjected to the therapeutic trial of high dose methyl prednisolone (MP; 9/9) and mannitol (M; 6/9) after their failure to the saline and plasma replacement. Following the high dose MP and M, a significant increment in the effective circulatory blood volume as reflected by the sustained increment in CVP, widening of PP and declining in PR as well as improvement in clinical tissue perfusion were established in 7 of these nine patients so treated.

摘要

9名儿童（4名男性，5名女性），年龄在2岁半至13岁之间，出现了与登革热休克综合征相关的组织灌注不良的体征和症状。在生理盐水和血浆置换治疗失败后，所有这9名患者都接受了大剂量甲基泼尼松龙（MP；9/9）和甘露醇（M；6/9）的治疗试验。在接受大剂量MP和M治疗后，这9名接受治疗的患者中有7名出现了有效循环血容量显著增加，表现为中心静脉压持续升高、脉压增宽和脉率下降，以及临床组织灌注改善。