Pavan Kumar P, Siva Bandi, Anand Ajay, Tiwari Ashok K, Vekata Rao C, Boustie Joel, Suresh Babu K
Centre for Natural Products and Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Department of Chemistry, Sri Venkateswara University, Tirupati 517502, India.
J Asian Nat Prod Res. 2020 Oct;22(10):976-988. doi: 10.1080/10286020.2019.1628024. Epub 2019 Jun 27.
Bioassay-guided separation of acetone extract from lichen (Delise ex Nyl.) Hale led to the isolation of six major phenolic constituents (). Compounds structures were established using NMR and mass spectral techniques. Further, to develop libraries on these scaffolds, a series of semi-synthetic derivatives were prepared () and investigated for their free-radicals (2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)) scavenging and advanced glycation end products (AGEs) formation inhibitory activities. Amongst tested derivatives, , and showed strong ABTS scavenging potentials comparable to Trolox. In addition, these derivatives also manifested moderate AGEs formation inhibitory activities. [Formula: see text].
对地衣（德利塞氏地衣，原名为尼尔氏地衣）（Hale）丙酮提取物进行生物测定导向分离，得到了六种主要酚类成分（）。利用核磁共振和质谱技术确定了化合物结构。此外，为了在这些支架上开发文库，制备了一系列半合成衍生物（），并对其清除自由基（2,2-二苯基-1-苦基肼和2,2'-偶氮双（3-乙基苯并噻唑啉-6-磺酸）（ABTS））和抑制晚期糖基化终产物（AGEs）形成的活性进行了研究。在测试的衍生物中，、和表现出与Trolox相当的强大ABTS清除潜力。此外，这些衍生物还表现出适度的抑制AGEs形成的活性。[化学式：见正文]
