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坦桑尼亚北部腹部创伤患者手术治疗的模式与结果:一项前瞻性单中心观察性研究

Patterns and outcomes of patients with abdominal trauma on operative management from northern Tanzania: a prospective single centre observational study.

作者信息

Ntundu Shilanaiman Hilary, Herman Ayesiga M, Kishe Alfred, Babu Heri, Jahanpour Ola F, Msuya David, Chugulu Samuel G, Chilonga Kondo

机构信息

Department of General surgery, Kilimanjaro Christian Medical Centre, P.O. Box 3010, Moshi, Tanzania.

Kilimanjaro Christian Medical University College, P.O Box 2240, Moshi, Tanzania.

出版信息

BMC Surg. 2019 Jun 26;19(1):69. doi: 10.1186/s12893-019-0530-8.

Abstract

BACKGROUND

The abdomen is one of the most commonly injured regions in trauma patients. Abdominal injury surgeries are common in Tanzania and in many parts of the world. This study aimed to determine the relationships among the causes, characteristics, patterns and outcomes of abdominal injury patients undergoing operations at Kilimanjaro Christian Medical Centre.

METHODS

A prospective observational study was performed over a period of 1 year from August 2016 to August 2017. A case was defined as a trauma patient with abdominal injuries admitted to the general surgery department and undergoing an operation. We assessed injury types, patterns, aetiologies and outcomes within 30 days. The outcomes were post-operative complications and mortality. Multivariate logistic regression was used to explore the association between factors associated with morbidity and mortality.

RESULTS

Out of 136 patients, 115 (84.6%) were male, with a male-to-female ratio of 5.5:1. The most affected patients were in the age range of 21-40 years old, which accounted for 67 patients (49.3%), with a median age (IQR) of 31.5 (21.3-44.8) years. A majority (99 patients; 72.8%) had blunt abdominal injury, with a blunt-to-penetrating ratio of 2.7:1. The most common cause of injury was road traffic accidents (RTAs; 73 patients; 53.7%). Commonly injured organs in blunt and penetrating injuries were, respectively, the spleen (33 patients; 91.7%) and small bowel (12 patients; 46.1%). Most patients (89; 65.4%) had associated extra-abdominal injuries. Post-operative complications were observed in 57 patients (41.9%), and the mortality rate was 18 patients (13.2%). In the univariate analysis, the following were significantly associated with mortality: associated extra-abdominal injury (odds ratio (OR): 4.9; P-value< 0.039); head injury (OR: 4.4; P-value < 0.005); pelvic injury (OR: 3.9; P-value< 0.043); length of hospital stay (LOS) ≥ 7 days (OR: 4.2; P-value < 0.022); severe injury on the New Injury Severity Score (NISS) (OR: 21.7; P-value < 0.003); time > 6 h from injury to admission (OR: 4.4; P-value < 0.025); systolic BP < 90 (OR: 3.5; P-value < 0.015); and anaemia (OR: 4.7; P-value< 0.006). After adjustment, the following significantly predicted mortality: severe injury on the NISS (17 patients; 25.8%; adjusted odds ratio (aOR): 15.5, 95% CI: 1.5-160, P-value < 0.02) and time > 6 h from injury to admission (15 patients; 19.2%; aOR: 4.3, 95% CI: 1.0-18.9, P-value < 0.05).

CONCLUSION

Blunt abdominal injury was common and mostly associated with RTAs. Associated extra-abdominal injury, injury to the head or pelvis, LOS ≥ 7 days, systolic BP < 90 and anaemia were associated with mortality. Severe injury on the NISS and time > 6 h from injury to admission significantly predicted mortality.

摘要

背景

腹部是创伤患者中最常受伤的部位之一。腹部损伤手术在坦桑尼亚及世界许多地区都很常见。本研究旨在确定在乞力马扎罗基督教医疗中心接受手术的腹部损伤患者的病因、特征、模式和结局之间的关系。

方法

2016年8月至2017年8月进行了为期1年的前瞻性观察研究。病例定义为入住普通外科并接受手术的腹部损伤创伤患者。我们评估了30天内的损伤类型、模式、病因和结局。结局指标为术后并发症和死亡率。采用多因素logistic回归分析探讨与发病率和死亡率相关因素之间的关联。

结果

136例患者中,115例(84.6%)为男性,男女比例为5.5∶1。受影响最严重的患者年龄在21 - 40岁之间,共67例(49.3%),中位年龄(四分位间距)为31.5(21.3 - 44.8)岁。大多数(99例;72.8%)患者为钝性腹部损伤,钝性与穿透性损伤比例为2.7∶1。最常见的损伤原因是道路交通事故(RTA;73例;53.7%)。钝性和穿透性损伤中最常受伤的器官分别是脾脏(33例;91.7%)和小肠(12例;46.1%)。大多数患者(89例;65.4%)伴有腹部外损伤。57例患者(41.9%)出现术后并发症,死亡率为18例(13.2%)。单因素分析中,以下因素与死亡率显著相关:伴有腹部外损伤(比值比(OR):4.9;P值<0.039);头部损伤(OR:4.4;P值<0.005);骨盆损伤(OR:3.9;P值<0.043);住院时间(LOS)≥7天(OR:4.2;P值<0.022);新损伤严重程度评分(NISS)为重伤(OR:21.7;P值<0.003);受伤至入院时间>6小时(OR:4.4;P值<0.025);收缩压<90(OR:3.5;P值<0.015);以及贫血(OR:4.7;P值<0.006)。调整后,以下因素显著预测死亡率:NISS为重伤(17例;25.8%;调整后比值比(aOR):15.5,95%可信区间:1.5 - 160,P值<0.02)和受伤至入院时间>6小时(15例;19.2%;aOR:4.3,95%可信区间:1.0 - 18.9,P值<0.05)。

结论

钝性腹部损伤常见,且大多与道路交通事故相关。伴有腹部外损伤、头部或骨盆损伤、住院时间≥7天、收缩压<90和贫血与死亡率相关。NISS为重伤和受伤至入院时间>6小时显著预测死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e354/6595599/177994ccf524/12893_2019_530_Fig1_HTML.jpg

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