无 IL-18BP？避免 HAV。
No IL-18BP? Avoid HAV.
机构信息
Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO
出版信息
J Exp Med. 2019 Aug 5;216(8):1728-1729. doi: 10.1084/jem.20190841. Epub 2019 Jun 26.
Abstract
Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of , Belkaya et al. (https://doi.org/10.1084/jem.20190669) identify a deletion in the gene in a severely affected child that results in excessive natural killer cell activation and uncontrolled killing of hepatocytes.
摘要
暴发性病毒性肝炎发生在极少数受感染个体中。到目前为止，这种表型的基础仍不清楚。在本期《 》杂志中，Belkaya 等人（https://doi.org/10.1084/jem.20190669）在一名重症患儿中发现了 基因缺失，导致自然杀伤细胞过度激活和肝细胞失控性杀伤。
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