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Clotrimazole troches can alter everolimus pharmacokinetics in post-transplant patients: A case report.

作者信息

Uno Takaya, Wada Kyoichi, Matsuda Sachi, Ikura Megumi, Takenaka Hiromi, Terakawa Nobue, Oita Akira, Yokoyama Satoshi, Kawase Atsushi, Hosomi Kouichi, Takada Mitsutaka

机构信息

Department of Pharmacy, National Cerebral and Cardiovascular Center, Suita, Japan.

Division of Clinical Drug Informatics, School of Pharmacy, Kindai University, Higashi-osaka, Japan.

出版信息

Br J Clin Pharmacol. 2019 Sep;85(9):2176-2178. doi: 10.1111/bcp.14017. Epub 2019 Jun 26.

DOI:10.1111/bcp.14017
PMID:31243774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6710514/
Abstract
摘要

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1
Clotrimazole troches can alter everolimus pharmacokinetics in post-transplant patients: A case report.克霉唑含片可改变移植后患者的依维莫司药代动力学：一例报告。
Br J Clin Pharmacol. 2019 Sep;85(9):2176-2178. doi: 10.1111/bcp.14017. Epub 2019 Jun 26.
2
Effects of clotrimazole troches on tacrolimus dosing in heart transplant recipients.克霉唑含片对心脏移植受者他克莫司给药剂量的影响。
Transpl Infect Dis. 2018 Dec;20(6):e12979. doi: 10.1111/tid.12979. Epub 2018 Sep 3.
3
Clinically Significant Drug Interaction Between Clotrimazole and Tacrolimus in Pancreas Transplant Recipients and Associated Risk of Allograft Rejection.胰腺移植受者中克霉唑与他克莫司之间具有临床意义的药物相互作用及同种异体移植排斥反应的相关风险。
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Prophylaxis of oral candidiasis with clotrimazole troches.克霉唑含片预防口腔念珠菌病
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A pharmacological rationale for improved everolimus dosing in oncology and transplant patients.在肿瘤学和移植患者中优化依维莫司给药的药理学原理。
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Comparison of the efficacy of a novel sustained release clotrimazole varnish and clotrimazole troches for the treatment of oral candidiasis.新型缓释克霉唑清漆与克霉唑含片治疗口腔念珠菌病的疗效比较。
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A comparative trial of clotrimazole troches and oral nystatin suspension in recipients of renal transplants. Use in prophylaxis of oropharyngeal candidiasis.克霉唑含片与口服制霉菌素混悬液在肾移植受者中的对比试验。用于预防口咽念珠菌病。
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Drug interactions between tacrolimus and clotrimazole troche: a data mining approach followed by a pharmacokinetic study.他克莫司与克霉唑锭之间的药物相互作用：数据挖掘方法及随后的药代动力学研究。
Eur J Clin Pharmacol. 2020 Jan;76(1):117-125. doi: 10.1007/s00228-019-02770-6. Epub 2019 Oct 26.
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Everolimus overexposure in a heart transplant patient receiving clarithromycin for the treatment of pneumonia.一名接受克拉霉素治疗肺炎的心脏移植患者出现依维莫司暴露过量情况。
Transpl Infect Dis. 2015 Dec;17(6):926-8. doi: 10.1111/tid.12446. Epub 2015 Oct 28.

本文引用的文献

1
Effects of clotrimazole troches on tacrolimus dosing in heart transplant recipients.克霉唑含片对心脏移植受者他克莫司给药剂量的影响。
Transpl Infect Dis. 2018 Dec;20(6):e12979. doi: 10.1111/tid.12979. Epub 2018 Sep 3.
2
Effect of fluconazole on the pharmacokinetics of everolimus and tacrolimus in a heart transplant recipient: Case report.氟康唑对一名心脏移植受者中依维莫司和他克莫司药代动力学的影响：病例报告
Int J Clin Pharmacol Ther. 2018 Jun;56(6):270-276. doi: 10.5414/CP203209.
3
Optimizing everolimus exposure when combined with calcineurin inhibitors in solid organ transplantation.优化在实体器官移植中与钙调磷酸酶抑制剂联合使用时的依维莫司暴露量。
Transplant Rev (Orlando). 2017 Jul;31(3):151-157. doi: 10.1016/j.trre.2017.02.007. Epub 2017 Feb 27.
4
Clinically Significant Drug Interaction Between Clotrimazole and Tacrolimus in Pancreas Transplant Recipients and Associated Risk of Allograft Rejection.胰腺移植受者中克霉唑与他克莫司之间具有临床意义的药物相互作用及同种异体移植排斥反应的相关风险。
Pharmacotherapy. 2016 Mar;36(3):335-41. doi: 10.1002/phar.1718. Epub 2016 Mar 11.
5
Randomized, double-blind trial of anidulafungin versus fluconazole for prophylaxis of invasive fungal infections in high-risk liver transplant recipients.随机、双盲临床试验：阿尼芬净对比氟康唑用于高危肝移植受者侵袭性真菌感染的预防。
Am J Transplant. 2014 Dec;14(12):2758-64. doi: 10.1111/ajt.12963. Epub 2014 Nov 6.
6
Latex-enhanced turbidimetric immunoassay for everolimus in whole blood using the Nanopia TDM everolimus assay with the JCA-BM6010 automatic analyzer.使用Nanopia依维莫司治疗药物监测检测法及JCA - BM6010自动分析仪对全血中的依维莫司进行乳胶增强比浊免疫分析。
Ther Drug Monit. 2014 Oct;36(5):677-80. doi: 10.1097/FTD.0000000000000057.
7
Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes.关注肾移植中的mTOR抑制剂和他克莫司：药代动力学、暴露-反应关系及临床结局。
Transpl Immunol. 2014 Jun;31(1):22-32. doi: 10.1016/j.trim.2014.05.002. Epub 2014 May 24.
8
Duration of drug interactions: putative time courses after mechanism-based inhibition or induction of CYPs.药物相互作用的持续时间：基于机制的细胞色素P450酶抑制或诱导后的假定时间进程。
Expert Rev Clin Pharmacol. 2011 Jul;4(4):409-11. doi: 10.1586/ecp.11.30.
9
Effects of oral clotrimazole troches on the pharmacokinetics of oral and intravenous midazolam.克霉唑口含片对口服和静脉注射咪达唑仑药代动力学的影响。
Br J Clin Pharmacol. 2010 Feb;69(2):160-6. doi: 10.1111/j.1365-2125.2009.03559.x.
10
The enzymatic basis of drug-drug interactions with systemic triazole antifungals.全身性三唑类抗真菌药药物相互作用的酶学基础。
Clin Pharmacokinet. 2008;47(12):779-92. doi: 10.2165/0003088-200847120-00003.