Fitzgerald Stephen P, Grote Beverborg Niels, Beguin Yves, Artunc Ferruh, Falhammar Henrik, Bean Nigel G
Departments of General Medicine and Endocrinology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Physiol Rep. 2019 Jul;7(12):e14153. doi: 10.14814/phy2.14153.
Hemoglobin levels are believed to be regulated as per a set point model of regulation. This model of regulation, by which specific levels of a parameter are targeted and defended by physiological systems, implies a particular population correlation between the parameter and its controlling hormone. Empirical population correlations of other parameters and their controlling hormones, have denied the presence of such set point-based regulation. To assess if hemoglobin is regulated according to a set point model we performed a systematic search of PubMed/MEDLINE and Web of Science identifying relevant reports published up to November 2018. Population hemoglobin/erythropoietin level correlations were retrieved, and these empirically derived correlations were compared with the positive correlation implied by a set point model of regulation. Authors of papers containing potentially suitable data were contacted with requests for further analyses, and a meta-analysis was performed. Twelve correlations between hemoglobin and erythropoietin levels from eleven papers were analyzed. None of these correlations were significantly positive, three, restricted to the normal range of hemoglobin, were significantly negative. All but one of the other correlations showed a negative trend. New analyses of previously published data sets resulted in similar findings. In particular a new analysis of large data sets of males (n = 2417) and females (n = 2592) with normal range hemoglobin levels, revealed significantly negative correlations. A meta-analysis of our results indicated that the data overall are not consistent with a positive relationship between hemoglobin and erythropoietin (P < 0.0001). Population data indicate that individuals do not have set point levels of hemoglobin.
血红蛋白水平被认为是按照一种设定点调节模型进行调节的。这种调节模型中，生理系统会针对特定参数水平进行靶向调节并维持其稳定，这意味着该参数与其控制激素之间存在特定的群体相关性。然而，其他参数与其控制激素的经验性群体相关性研究却否定了这种基于设定点的调节方式的存在。为了评估血红蛋白是否按照设定点模型进行调节，我们对PubMed/MEDLINE和Web of Science进行了系统检索，以找出截至2018年11月发表的相关报告。我们检索了群体血红蛋白/促红细胞生成素水平的相关性，并将这些基于经验得出的相关性与设定点调节模型所暗示的正相关性进行了比较。我们联系了包含潜在合适数据的论文作者，请求进行进一步分析，并进行了荟萃分析。我们分析了11篇论文中血红蛋白与促红细胞生成素水平之间的12个相关性。这些相关性均无显著的正相关，其中3个（仅限于血红蛋白的正常范围）呈显著负相关。除一个之外，其他所有相关性均呈负趋势。对先前发表的数据集进行的新分析也得出了类似的结果。特别是对血红蛋白水平在正常范围内的大量男性（n = 2417）和女性（n = 2592）数据集进行的新分析，显示出显著的负相关性。我们对结果的荟萃分析表明，总体数据并不支持血红蛋白与促红细胞生成素之间存在正相关关系（P < 0.0001）。群体数据表明，个体并没有设定的血红蛋白水平。
