da Silva Renata de Melo Felipe, Batistuzzo Marcelo Camargo, Shavitt Roseli Gedanke, Miguel Eurípedes Constantino, Stern Emily, Mezger Eva, Padberg Frank, D'Urso Giordano, Brunoni Andre R
Department and Institute of Psychiatry, Obsessive-Compulsive Spectrum Disorders Program, Laboratory of Psychopathology and Psychiatric treatment (LIM-23), Service of Interdisciplinary Neuromodulation (SIN), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo , Sao Paulo , Brazil.
Department and Institute of Psychiatry, Obsessive-Compulsive Spectrum Disorders Program, Laboratory of Psychopathology and Psychiatric treatment (LIM-23), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo , Sao Paulo , Brazil.
Expert Rev Neurother. 2019 Oct;19(10):1025-1035. doi: 10.1080/14737175.2019.1637257. Epub 2019 Jul 8.
: Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation intervention that has been investigated for several psychiatric disorders, including Obsessive-Compulsive Disorder (OCD). As there are several candidate brain regions for targeting OCD relevant networks, clinical studies using tDCS have considerably varied in terms of the electrode montages used. Computer modeling of electric field currents induced by tDCS can help guiding the research of relevant targets for OCD. In this review, the authors used this tool to investigate targeted brain areas from previous studies of tDCS in OCD. : A literature search for articles with the keywords 'tDCS', 'Transcranial Direct Current Stimulation' and 'Obsessive Compulsive Disorder' was conducted to identify relevant publications. For comparing different electrode montages, electric field (EF) models were performed using high-resolution brain scan templates. Authors found 13 studies mostly showing an improvement in OCD symptoms. The electrode montages varied considerably between studies. Nonetheless, two main patterns of EFs could be identified: 'focal montages', with EFs concentrated in the prefrontal cortex, and 'diffuse montages', with widespread EFs over cortical areas. : Electric field simulation can guide future clinical trials in psychiatry, using personalized tDCS montages with distinct electrode positioning according to clusters of symptoms.
经颅直流电刺激（tDCS）是一种非侵入性脑刺激干预手段，已针对包括强迫症（OCD）在内的多种精神疾病进行了研究。由于有多个候选脑区可作为强迫症相关网络的靶点，使用tDCS的临床研究在所用电极组合方面差异很大。tDCS诱发的电场电流的计算机建模有助于指导强迫症相关靶点的研究。在本综述中，作者使用该工具研究了以往强迫症tDCS研究中的靶向脑区。：通过对关键词为“tDCS”、“经颅直流电刺激”和“强迫症”的文章进行文献检索，以确定相关出版物。为了比较不同的电极组合，使用高分辨率脑扫描模板进行电场（EF）模型分析。作者发现13项研究大多显示强迫症症状有所改善。不同研究之间的电极组合差异很大。尽管如此，可以识别出两种主要的电场模式：“聚焦组合”，电场集中在前额叶皮层；“弥散组合”，电场分布在整个皮层区域。：电场模拟可以指导未来的精神病学临床试验，根据症状群使用具有不同电极定位的个性化tDCS组合。
