维拉帕米对血小板表面超微结构及钙含量的影响。
Effect of verapamil on platelet surface ultrastructure and calcium content.
作者信息
Djaldetti M, Gilgal R, Fishman P, Zahavi I
机构信息
Department of Medicine B, Tel Aviv University Medical School, Petah-Tiqva, Israel.
出版信息
Acta Haematol. 1988;79(1):41-3. doi: 10.1159/000205688.
PMID:3124459
Abstract
The effect of verapamil on the surface ultrastructure and calcium content of human platelets was studied by scanning electron microscopy and X-ray microanalysis. The results showed that the drug prevents platelet pseudopodia formation and causes a dose-dependent inhibition of platelet calcium concentration. The significance of these findings in the explanation of the inhibitory effect of verapamil on platelet aggregation is discussed.
摘要
通过扫描电子显微镜和X射线微量分析研究了维拉帕米对人血小板表面超微结构和钙含量的影响。结果表明，该药物可阻止血小板伪足形成，并导致血小板钙浓度呈剂量依赖性抑制。讨论了这些发现对解释维拉帕米对血小板聚集抑制作用的意义。
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