Biomolecular and Genetic Laboratory (LABIOGENE), Pietro Annigoni Biomolecular Research Center (CERBA), Department of Biochemistry-Microbiology, University Ouaga I Prof Joseph Ki Zerbo, BP 364, Ouagadougou, Burkina Faso.
Bacteriology Laboratory, National Institute of Hygiene (INH), BP 1396, Lomé, Togo.
Antimicrob Resist Infect Control. 2019 Jun 18;8:104. doi: 10.1186/s13756-019-0552-0. eCollection 2019.
genes are known to confer a low-level resistance to fluoroquinolone in . They are often found on the same resistance plasmids as extended spectrum β-lactamase (ESBL) and constitute the most common antibiotic resistance mechanism. This study aimed to detect the presence of r genes in -producing and .
From May 2013 to July 2015, 91 and 64 strains with phenotypic resistance to quinolone were collected from several specimens and analyzed for the detection of genes and the β-lactamase resistance genes (, , ) using simplex and multiplex PCR.
In the present study, 107 (69%; 61 and 46 ) of 155 bacterial strains tested were found harboring at least one gene consisting of 74 (47.74%) , 73 (47.10%) and 4 (2.58%) . Of the 107 strains encoding genes, 102, 96 and 52 carried , and type ESBL respectively.
This study identified quinolone resistance () gene in -producing and in Togo. These finding which suggest a possible resistance to quinolone are of high interest for better management of patients and control of antimicrobial resistance in Togo.
已知基因在. 中赋予氟喹诺酮的低水平耐药性。它们通常与扩展谱β-内酰胺酶（ESBL）存在于同一耐药质粒上，是最常见的抗生素耐药机制。本研究旨在检测产. 的. 中 r 基因的存在。
从 2013 年 5 月至 2015 年 7 月，从几个标本中收集了 91 株和 64 株对喹诺酮表型耐药的. 和. 菌株，使用单重和多重 PCR 检测 r 基因和β-内酰胺酶耐药基因（、、）。
在本研究中，在 155 株测试的细菌菌株中，发现有 107 株（69%；61 株. 和 46 株. ）至少携带一个. 基因，包括 74 株（47.74%）. 、73 株（47.10%）. 和 4 株（2.58%）. 。在携带. 基因的 107 株菌株中，有 102、96 和 52 株分别携带. 、. 和. 型 ESBL。
本研究在. 产. 和. 中鉴定出了氟喹诺酮耐药（）基因。这些发现提示. 可能对喹诺酮类药物耐药，这对于改善多哥患者的管理和控制抗菌药物耐药性具有重要意义。
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