边缘型人格障碍患者的多种神经内分泌反应。

Multiple neuroendocrinological responses in borderline personality disorder patients.

作者信息

Kontaxakis V, Markianos M, Vaslamatzis G, Markidis M, Kanellos P, Stefanis C

机构信息

Department of Psychiatry, Athens University Medical School, Eginition Hospital, Greece.

出版信息

Acta Psychiatr Scand. 1987 Nov;76(5):593-7. doi: 10.1111/j.1600-0447.1987.tb02924.x.

DOI:10.1111/j.1600-0447.1987.tb02924.x

PMID:3124503

Abstract

Male patients suffering from borderline personality disorder (n = 13), major depression (n = 13) or schizophrenia (n = 13) were investigated on several psychopathological (HDRS, BPRS) and neuroendocrinological (DST and TSH, PRL, GH responses to TRH) parameters. Comparisons were made between the borderline group and the other groups of patients. Borderline patients differed from schizophrenics psychopathologically (BPRS) and neuroendocrinologically (DST). Also, borderline patients differed from major depressives in the HDRS, but behaved like them concerning DST. Our findings support the hypothesis that there are neuroendocrinological similarities between borderline personality disorder and major depressive patients, especially on the hypothalamo-pituitary-adrenal axis.

摘要

对患有边缘型人格障碍（n = 13）、重度抑郁症（n = 13）或精神分裂症（n = 13）的男性患者进行了多项心理病理学（汉密尔顿抑郁量表、简明精神病评定量表）和神经内分泌学（地塞米松抑制试验以及促甲状腺激素、催乳素、生长激素对促甲状腺激素释放激素的反应）参数的研究。对边缘型人格障碍组与其他患者组进行了比较。边缘型人格障碍患者在心理病理学（简明精神病评定量表）和神经内分泌学（地塞米松抑制试验）方面与精神分裂症患者不同。此外，边缘型人格障碍患者在汉密尔顿抑郁量表上与重度抑郁症患者不同，但在地塞米松抑制试验方面表现与他们相似。我们的研究结果支持这样的假设，即边缘型人格障碍与重度抑郁症患者之间存在神经内分泌学相似性，尤其是在下丘脑 - 垂体 - 肾上腺轴方面。