[镓]-喷替沙氟PET/CT用于前庭神经鞘瘤的CXCR4介导成像
[Ga]-Pentixafor PET/CT for CXCR4-Mediated Imaging of Vestibular Schwannomas.
作者信息
Breun Maria, Monoranu Camelia M, Kessler Almuth F, Matthies Cordula, Löhr Mario, Hagemann Carsten, Schirbel Andreas, Rowe Steven P, Pomper Martin G, Buck Andreas K, Wester Hans-Jürgen, Ernestus Ralf-Ingo, Lapa Constantin
机构信息
Department of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.
Department of Neuropathology, University of Würzburg, Institute of Pathology, Würzburg, Germany.
出版信息
Front Oncol. 2019 Jun 12;9:503. doi: 10.3389/fonc.2019.00503. eCollection 2019.
We have recently demonstrated CXCR4 overexpression in vestibular schwannomas (VS). This study investigated the feasibility of CXCR4-directed positron emission tomography/computed tomography (PET/CT) imaging of VS using the radiolabeled chemokine ligand [Ga]Pentixafor. 4 patients with 6 primarily diagnosed or pre-treated/observed VS were enrolled. All subjects underwent [Ga]Pentixafor PET/CT prior to surgical resection. Images were analyzed visually and semi-quantitatively for CXCR4 expression including calculation of tumor-to-background ratios (TBR). Immunohistochemistry served as standard of reference in three patients. [Ga]Pentixafor PET/CT was visually positive in all cases. SUV and SUV were 3.0 ± 0.3 and 3.8 ± 0.4 and TBR and TBR were 4.0 ± 1.4 and 5.0 ± 1.7, respectively. Histological analysis confirmed CXCR4 expression in tumors. Non-invasive imaging of CXCR4 expression using [Ga]Pentixafor PET/CT of VS is feasible and could prove useful for assessment of CXCR4 expression.
我们最近证实了前庭神经鞘瘤（VS）中CXCR4的过表达。本研究使用放射性标记的趋化因子配体[镓]喷替沙福，调查了VS的CXCR4导向正电子发射断层扫描/计算机断层扫描（PET/CT）成像的可行性。招募了4例患有6个主要诊断或预处理/观察到的VS患者。所有受试者在手术切除前均接受了[镓]喷替沙福PET/CT检查。对图像进行了视觉和半定量分析，以评估CXCR4表达，包括计算肿瘤与背景比值（TBR）。免疫组织化学作为3例患者的参考标准。[镓]喷替沙福PET/CT在所有病例中视觉上均为阳性。SUV和SUV分别为3.0±0.3和3.8±0.4，TBR和TBR分别为4.0±1.4和5.0±1.7。组织学分析证实肿瘤中存在CXCR4表达。使用[镓]喷替沙福PET/CT对VS的CXCR4表达进行无创成像可行，且可能对评估CXCR4表达有用。
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