School of Mongol medicine, Inner Mongolia University for Nationalities, Tongliao, China.
Department of Mongolian Dermatology, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, China.
J Cosmet Dermatol. 2019 Aug;18(4):1009-1013. doi: 10.1111/jocd.12883. Epub 2019 Jun 6.
Alopecia areata (AA) is a relatively common dermatosis with the sudden burst of hair loss on the scalp and other hair-bearing regions. However, because of high relapse and side effects, no satisfactory therapy has been widely accepted.
To observe the efficiency and safety of the combination therapy of a nonablative fractional (NAF) laser and topical minoxidil for AA.
Eight Chinese AA patients were included in this study. These patients received 10 treatments every two weeks. At every time, the subject was given 10 to 15 mJ of energy with a total intensity of 300 spots/cm . After the laser treatment, a topical 5% minoxidil tincture was immediately applied twice daily and continued until the final laser treatment.
Hair regrowth was observed 1-2 months after treatment. There was complete regrowth in 2 patients, and the lesions of 2 children with alopecia universalis were covered with 30% and 50% regrowth, respectively. All patients except 1 had no relapse at the 1-year follow-up examination.
The combination of nonablative laser and topical minoxidil may be a good alternative therapy for AA patients, including alopecia totalis and alopecia universalis, without systemic and local side effects.
斑秃（AA）是一种较为常见的皮肤病，表现为头皮及其他毛发部位突然出现脱发斑。然而，由于高复发率和副作用，尚未广泛接受令人满意的治疗方法。
观察非剥脱性点阵激光联合外用米诺地尔治疗斑秃的疗效和安全性。
本研究纳入 8 例中国斑秃患者。这些患者每两周接受 10 次治疗。每次治疗时，给予 10-15mJ 能量，总强度为 300 点/cm²。激光治疗后，立即每日外用 5%米诺地尔酊 2 次，并持续至最后一次激光治疗。
治疗后 1-2 个月观察到毛发再生。2 例患者完全再生，2 例全秃患儿的病变分别有 30%和 50%再生。除 1 例患者外，所有患者在 1 年随访时均无复发。
非剥脱性激光联合外用米诺地尔可能是一种治疗斑秃患者（包括全秃和普秃）的良好替代疗法，无全身和局部副作用。
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