Vanderveen E E, Ellis C N, Kang S, Case P, Headington J T, Voorhees J J, Swanson N A
J Am Acad Dermatol. 1984 Sep;11(3):416-21. doi: 10.1016/s0190-9622(84)70183-6.
Minoxidil, a potent peripheral vasodilator used orally for refractory hypertension, has produced hypertrichosis. To determine the efficacy and safety of 1% or 5% topical minoxidil for the stimulation of scalp hair regrowth, we studied fifteen normotensive patients, five with androgenic alopecia and ten with alopecia areata diagnosed clinically and by biopsy, for 12 months. Three of five patients with androgenic alopecia using 5% minoxidil for 12 months noted hair regrowth, ranging from minimally observable hair to an appreciable restoration of larger, pigmented, terminal hair in one patient. Among the patients with androgenic alopecia, regrowth response corresponded to the serum minoxidil blood levels. None of the patients with alopecia areata receiving either 1% or 5% minoxidil noted hair regrowth despite comparable minoxidil blood levels. Improved local absorption of topical minoxidil solution may promote hair regrowth in androgenic alopecia.
米诺地尔是一种强效外周血管扩张剂，口服用于治疗难治性高血压，可导致多毛症。为了确定1%或5%外用米诺地尔刺激头皮毛发生长的疗效和安全性，我们对15名血压正常的患者进行了为期12个月的研究，其中5名患有雄激素性脱发，10名经临床和活检诊断为斑秃。5名使用5%米诺地尔治疗12个月的雄激素性脱发患者中有3名注意到有毛发生长，从几乎观察不到的毛发到1名患者明显恢复了更大、有色素的终毛。在雄激素性脱发患者中，毛发生长反应与血清米诺地尔血药浓度相关。尽管米诺地尔血药浓度相当，但接受1%或5%米诺地尔治疗的斑秃患者均未注意到有毛发生长。外用米诺地尔溶液局部吸收的改善可能会促进雄激素性脱发患者的毛发生长。
