Orthoclone OKT3单克隆抗体在肝移植中的应用经验。
Experience with Orthoclone OKT3 monoclonal antibody in liver transplantation.
作者信息
Gordon R D, Tzakis A G, Iwatsuki S, Todo S, Esquivel C O, Marsh J W, Stieber A, Makowka L, Starzl T E
机构信息
Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, PA.
出版信息
Am J Kidney Dis. 1988 Feb;11(2):141-4. doi: 10.1016/s0272-6386(88)80199-9.
Experience with the use of Orthoclone OKT3 monoclonal antibody for the treatment of acute cellular rejection in a series of 130 human orthotopic liver transplantations is reviewed. Treatment was highly effective in reversing rejection, in reducing the rate of retransplantation, and in lowering patient mortality. OKT3 was also useful for cyclosporine sparing in patients with poor renal function, hypertension, or CNS toxicity. There was a significant incidence of opportunistic infection associated with the use of OKT3.
回顾了在130例人类原位肝移植中使用Orthoclone OKT3单克隆抗体治疗急性细胞排斥反应的经验。该治疗在逆转排斥反应、降低再次移植率和降低患者死亡率方面非常有效。OKT3对肾功能差、高血压或中枢神经系统毒性患者减少环孢素用量也很有用。使用OKT3会有明显的机会性感染发生率。
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