, , and single nucleotide polymorphisms associated with distal radius fracture in postmenopausal Mexican women.

The aim of this study was to analyze the genetic association of five single nucleotide polymorphisms (SNPs) (rs3020331, rs851982, rs1999805, rs2234693, rs3020404), four SNPs (rs1800012, rs2075555, rs2412298, rs1107946), and two SNPs on the gene (rs9479055, rs4870044) with distal radius fracture (DRF) in a group of postmenopausal Mexican women. A case-control study was conducted. Cases ( = 182) were women above the age of 38 years with low-energy DRF, and controls ( = 201) were women without. Analysis was done through real-time polymerase chain reaction. Frequencies and Hardy-Weinberg equilibrium were calculated. A multivariate analysis including bone mass index, age, menarche, and menopause as covariables was carried out. Finally, haplotype and linkage disequilibrium (LD) analyses were performed. rs1107946 was strongly associated with DRF. Both SNPs showed strong association with DRF. For the gene, four SNPs (rs2234693, 3020404, rs3020331, and rs851982) showed very strong association with DRF. Additionally, the region between the latter two showed strong LD. A strong association of DRF with variants in these genes was found, including haplotypes and a region with strong LD on . The results suggest that these SNPs could be useful to detect the population at risk of presenting DRF among Mexican perimenopausal women.