O'Keane J A, Yuen B H, Farquharson D F, Wittmann B K
Department of Obstetrics and Gynecology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Am J Obstet Gynecol. 1988 Feb;158(2):364-7. doi: 10.1016/0002-9378(88)90156-1.
With the increase of medical induction of ovulation, the incidence of grand multiple pregnancy is becoming more frequent. We report the endocrine response of a quintuplet pregnancy that was reduced at 9 weeks' gestation to a twin pregnancy by selective embryocide and compared with quadruplet, triplet, and twin pregnancies. The human chorionic gonadotropin titer declined fourfold, but there were no clinically significant changes in the progesterone or estradiol levels. We conclude that, despite the drop in human chorionic gonadotropin, the placenta had attained adequate secretory maturation to prevent any significant decline in progesterone and estradiol levels, which demonstrates the efficacy of this procedure at this gestational age.
随着药物促排卵的增加，巨大多胎妊娠的发生率越来越高。我们报告了一例五胎妊娠在妊娠9周时通过选择性胚胎减灭术减为双胎妊娠后的内分泌反应，并与四胎、三胎和双胎妊娠进行了比较。人绒毛膜促性腺激素水平下降了四倍，但孕酮或雌二醇水平没有临床显著变化。我们得出结论，尽管人绒毛膜促性腺激素水平下降，但胎盘已达到足够的分泌成熟度，以防止孕酮和雌二醇水平出现任何显著下降，这证明了该手术在这个孕周的有效性。
