Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Clinical Pharmacy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Biofactors. 2019 Sep;45(5):690-702. doi: 10.1002/biof.1538. Epub 2019 Jun 27.
Drug-induced nephrotoxicity is a frequent serious adverse effect, contributing to morbidity and increased healthcare utilization. Prevention or reversal is key. Curcumin has useful biological features that include antioxidant, anti-inflammatory, and anticancer properties. This review covers aspects of curcumin in relation to prevention of drug-induced nephrotoxicity: dosage and schedule, effect on kidney biomarkers and histological changes, and mechanisms of curcumin's protective effects. Despite success in some animal models, human studies and clinical administration of curcumin for nephroprotection remains limited due to difficulty in achieving therapeutic levels following oral administration and in determining the optimal dosing schedule. Lack of sufficient evidence from animal studies, coupled with low systemic bioavailability, continues to limit the utilization of curcumin in addressing and controlling drug-induced nephrotoxicity. Therefore, human studies are required to fully assess and validate the therapeutic potential of curcumin.
药物性肾毒性是一种常见的严重不良反应，可导致发病率增加和医疗保健利用增加。预防或逆转是关键。姜黄素具有有用的生物学特性，包括抗氧化、抗炎和抗癌特性。本综述涵盖了姜黄素在预防药物性肾毒性方面的各个方面：剂量和方案、对肾脏生物标志物和组织学变化的影响，以及姜黄素保护作用的机制。尽管在一些动物模型中取得了成功，但由于口服后难以达到治疗水平以及确定最佳剂量方案，人类研究和临床应用姜黄素进行肾脏保护仍然受到限制。由于缺乏来自动物研究的充分证据，再加上系统生物利用度低，限制了姜黄素在解决和控制药物性肾毒性方面的应用。因此，需要进行人体研究来全面评估和验证姜黄素的治疗潜力。
