通过氢键催化实现苯并连接的轴手性吲哚的对映选择性合成。
An Atropo-enantioselective Synthesis of Benzo-Linked Axially Chiral Indoles via Hydrogen-Bond Catalysis.
作者信息
Liu Jin-Yu, Yang Xie-Chao, Liu Zhen, Luo Yong-Chun, Lu Hong, Gu Yu-Cheng, Fang Ran, Xu Peng-Fei
机构信息
State Key Laboratory of Applied Organic Chemistry, School of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 . P. R. China.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science , Northwest University , Xi'an 710069 , P. R. China.
出版信息
Org Lett. 2019 Jul 5;21(13):5219-5224. doi: 10.1021/acs.orglett.9b01828. Epub 2019 Jun 25.
A variety of axially chiral biaryldiols were synthesized in good yields with excellent atropo-enantioselectivities through construction of axially chiral indoles catalyzed by asymmetric hydrogen-bond donors. In addition, the new axially chiral compounds were proved to be efficient and practical catalysts for asymmetric catalysis. The strategy not only provides a novel method to synthesize axially chiral compounds but also extends the scope of chiral catalysts.
通过不对称氢键供体催化构建轴手性吲哚，以良好的产率和优异的阻转对映选择性合成了多种轴手性联芳基二醇。此外，新的轴手性化合物被证明是用于不对称催化的高效实用催化剂。该策略不仅提供了一种合成轴手性化合物的新方法，还扩展了手性催化剂的范围。
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