Wang Hai, Wu Xiao-Feng
Leibniz-Institut für Katalyse e.V.an der Universität Rostock , Albert-Einstein-Straße 29a , 18059 Rostock , Germany.
Org Lett. 2019 Jul 5;21(13):5264-5268. doi: 10.1021/acs.orglett.9b01868. Epub 2019 Jun 18.
An interesting palladium-catalyzed dearomative carbonylation of N-(2-bromobenzoyl)indoles has been developed. The catalytic system is composed of commercially available Pd(OAc) and DPPP and uses alcohols and anilines as nucleophiles to afford moderate to good yields of the desired products. This method provides a straightforward access to diverse fused indoline esters and amides with good functional group tolerance. Remarkably, this is the first example of carbonylative dearomatization.
已开发出一种有趣的钯催化的N-(2-溴苯甲酰基)吲哚去芳构化羰基化反应。该催化体系由市售的Pd(OAc)和DPPP组成，并使用醇类和苯胺作为亲核试剂，以中等至良好的产率得到所需产物。该方法为合成具有良好官能团耐受性的各种稠合吲哚啉酯和酰胺提供了一条直接的途径。值得注意的是，这是羰基化去芳构化的首个实例。
