Sugita O, Nagashima K, Sassa S, Kappas A
Rockefeller University, New York, N.Y.
Biochem Biophys Res Commun. 1988 Feb 15;150(3):925-30. doi: 10.1016/0006-291x(88)90717-6.
The localization and distribution of NADPH-cytochrome P450 reductase and cytochrome P450C-M/F were investigated immunohistochemically in the liver and the kidney of untreated rats employing both an unlabelled antibody peroxidase-antiperoxidase method and a peroxidase labelled primary antibody technique. In both immunohistochemical procedures, the reductase and P450C-M/F were detected in hepatocytes throughout the liver. In contrast, the reductase and P450C-M/F in the kidney were only detectable in the proximal tubule cells.
