NESMOS Department (Neuroscience, Mental Health, and Sensory Organs), School of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University, Rome, Italy.
Centro Lucio Bini, Rome, Italy.
CNS Spectr. 2020 Aug;25(4):449-451. doi: 10.1017/S1092852919001184. Epub 2019 Jun 28.
Lithium is a unique drug. In more than 60 years of observation, it showed its multiple important clinical properties in treating mania, stabilizing mood alterations, preventing suicide and protecting from neurodegeneration. It was also the most extensively studied drug in psychiatry. Nevertheless, it is generally underprescribed. Specifically, lithium is virtually not considered in the treatment of patients affected by mixed affective states. Lithium is not suggested for the acute treatment of mixed affective states and is considered to be less effective than other mood stabilizers in the long-term management of these patients. The main reason why lithium has no indication for mixed states is the "lack of evidence." Actually, there are several reasons to consider lithium as an effective treatment in patients with mixed affective states.
锂是一种独特的药物。在 60 多年的观察中，它在治疗躁狂症、稳定情绪变化、预防自杀和保护神经退行性变方面显示出多种重要的临床特性。它也是精神病学中研究最多的药物。然而，它的处方却普遍不足。具体来说，锂在治疗受混合情感状态影响的患者时几乎不被考虑。锂不建议用于急性治疗混合情感状态，并且被认为在这些患者的长期治疗中不如其他情绪稳定剂有效。锂对混合状态没有适应证的主要原因是“缺乏证据”。实际上，有几个理由可以考虑将锂作为混合情感状态患者的有效治疗方法。
