激活和抑制杀伤细胞免疫球蛋白样受体（KIR）基因参与增加结直肠腺瘤的易感性，并防止侵袭和转移。
Activating and inhibitory killer cell immunoglobulin like receptors (KIR) genes are involved in an increased susceptibility to colorectal adenocarcinoma and protection against invasion and metastasis.
机构信息
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Immunobiology. 2019 Sep;224(5):681-686. doi: 10.1016/j.imbio.2019.06.002. Epub 2019 Jun 20.
BACKGROUND
A set of activating and inhibitory KIRs (aKIR, iKIR) are involved in NK cell mediated immunity. This study was carried out in order to investigate the KIRs pattern and its association with colorectal carcinoma (CRC) development and clinical outcomes.
METHODS
Sequence-specific primers-polymerase chain reaction (SSP-PCR) for typing of 16 KIR genes was utilized in 165 patients with colorectal adenocarcinoma with 165 age and gender matched healthy controls (CNs).
RESULTS
Possessing KIR2DS1, 2DS5, 3DS1, 2DS4fl, 2DL5, telomeric half KIR genes, ≥ 4 aKIR and CXT4 genotype were associated with an increased susceptibility to colorectal adenocarcinoma while KIR2DS4del and iKIR >aKIR confer resistance to CRC. On the other hand, clinical associations revealed the defensive role of telomeric KIR3DL1, 3DS1, 2DS1, 2DS4, genotypes with ≥ 4 aKIR and more inhibitory KIRs than activating ones (I > A) against metastasis and CXTX genotype in perineural invasion.
CONCLUSION
According to current results it appears that KIRs system play distinctive roles in development and metastasis of colorectal adenocarcinoma.
背景
一组激活和抑制性杀伤细胞免疫球蛋白样受体（aKIR、iKIR）参与 NK 细胞介导的免疫。本研究旨在探讨 KIR 型与结直肠癌（CRC）发展和临床结局的关系。
方法
采用序列特异性引物聚合酶链反应（SSP-PCR）对 165 例结直肠腺癌患者和 165 例年龄和性别匹配的健康对照者（CNs）的 16 个 KIR 基因进行分型。
结果
携带 KIR2DS1、2DS5、3DS1、2DS4fl、2DL5、端粒半 KIR 基因、≥4 个 aKIR 和 CXT4 基因型与结直肠腺癌易感性增加相关，而 KIR2DS4del 和 iKIR>aKIR 则对 CRC 具有抗性。另一方面，临床相关性表明，端粒 KIR3DL1、3DS1、2DS1、2DS4、基因型≥4 个 aKIR 和更多抑制性 KIR （I>A）对转移和神经周围侵犯中的 CXTX 基因型具有防御作用。
结论
根据目前的结果，KIR 系统似乎在结直肠腺癌的发展和转移中发挥独特的作用。
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